Background: Oxidative stress is a key driver in the pathogenesis of oxidative-stress associated diseases, notably streptozotocin (STZ) induced-diabetes which is typically producen progressive pancreatic beta-cell destruction. Chia seeds (Salvia hispanica L.) are rich sources of plant polyphenols and omega-3 fatty acids that have antioxidant properties, but whether chia can protect against STZ-mediated beta-cell injury in rabbits had yet to be shown. The aim of the present study was to investigate the protective and therapeutic efficacy of chia seed ethanolic extract (CSEE) on pancreatic β-cell integrity, antioxidant status and some key biochemical indices in STZ- induce diabetic rabbits. Materials and Methods: Fourty male New Zealand White rabbits were randomly divided into four groups (n = 10 each): Group I (negative control, healthy), Group II (positive control STZ-induced diabetes) group III (CSEE treatment, oral at 400 mg/kg/day), and Group IV (CSEE prevention with STZ). A single intravenous injection of STZ (65 mg/kg) was performed to induce the diabetes. Animals were observed for 8 weeks. Both serum glucose, insulin, total antioxidant capacity (T-AOC), malondialdehyde (MDA), amylase and lipase were assayed. Histopathological examination of the pancreatic tissues. Results: Fasting blood glucose, MDA, serum amylase and lipase were significantly higher (p < 0.001)—whereas insulin and T-AOC were lower compared with healthy controls for STZ-induced diabetic rabbits. CSEE treatment significantly attenuated these parameters in the direction of normalization (p < 0.05). Histopathological examination showed abundant necrosis of islets, vacuolation in beta cells, and inflammatory infiltration in the diabetic group but were significantly alleviated in CSEE-treated animals. Conclusion: The ethanolic extract of chia seed protects the antioxidant and cytotoxic stress in STZ-induced diabetic rabbits, demonstrating its potential value as a natural adjunct to diabetes mellitus.

The present study was designed to describe of the morphological, histological, and immunohistochemical changes of the testis in local male rabbits (Oryctolagus cuniculus) postnatal period at age immature (45day), and mature(150day) with special emphasis on immunohistochemical-related components. This study was investigated to study the development of testis during postnatal periods. Thirty of male rabbit (Oryctolagus cuniculus) of postnatal period in two age (45 days immature and 150 days mature), were used in this study. Samples were collected by purchasing them from veterinary clinics. They were admitted to the university (Al - Qasim Green University) animal house and monitored for good health for 15 days. Morphological study10 rabbits, histological study 10 rabbits and immunohistochemistry 10rabbits (5for each age). The rabbits were then placed on the dissection stage after anesthesia. The weights of the rabbits were measured using an electronic balance. The rabbits were in good health, and the testicles were cut in the perineum after dissection. nAt age immature (45 day) the testis of male rabbits (Oryctolagus cuniculus) showed that located intra-abdominally on both sides near the kidneys, and the scrotum was not clearly developed. The testes appeared curved and elongated in shape with a dark brown coloration. Morphometrically, differences were observed between the left and right testes. The mean weight of the left testis was low with noticeable variation, while the right testis showed a lower mean weight with slight variation. The mean length of the left testis was greater with small variation, compared with a shorter length with small variation for the right testis. The mean width was larger with minimal variation for the left testis and smaller with minimal variation for the right testis.

Aquatic macrophytes play a critical role in the removal and sequestration of heavy metals from contaminated freshwater systems through bioaccumulation and phytoremediation processes. This study examines the capacity of two submerged aquatic plants, Ceratophyllum submersum and Ceratophyllum demersum, to accumulate nickel (Ni) and cobalt (Co) from aqueous environments. The study's findings showed physiological reactions such as lower protein content and a reduction in chlorophyll concentration, which affects photosynthesis. According to the study's findings, heavy metals have an impact on plants' evolutionary states through enzyme alterations, oxidative stress reactions, and pigmentation loss.