Background: Diazepines, the most commonly prescribed psychotropic drugs with anxiolytic action, may cause hyposalivation. Aim of Study: Is to throw light on the structural alternation in the rat parotid gland after administration of diazepam. Methods: Thirty male Wistar rats were divided into three groups. Control groups received a saline solution for 30 days. Group two and Group three salivary tissue was taken for histological assessment and biochemical assays. Results: The serous acinar cells were showed autolysis and nuclear changes (pyknosis, karyorrhexis, and karyolysis). There was an increase in the interstitial spaces between each parenchymal element associated with few mononuclear cell infiltrations. The intra-lobular ducts were reduced in size and were indistinct throughout lobes. Malondialdyhid (MDA) concentration had been increaseh high Significant (P≤0.01) in diazepam group of animals compared with control group. The diazepam group showed significantly decrease levels of GPX, SOD, GSH and CAT compared with the control group. Conclusion: Diazepam administration produces noticeable histological changes in a dosedependent manner associated with increased oxidative stress markers.

Background: Due to their high mineral and vitamin content, beetroot and onions, which are frequently utilized as antibiotics, antioxidants, and nutrients, are generating growing interest in their potential medical applications. Objective: The current study's is to separate the active components from beetroot and onions and use them as antimicrobial agents. Materials and Methods: A mixture of beetroot and onion in varying ratios, as well as fungal and bacterial cultures, were created for testing. Various procedures, including hot water, were utilized to extract the active components. Results: According to the findings, hot alcohol was used to extract the components that were the most active. Depending on the concentration of the active ingredients in the extract solution, the extracts exhibit varying bioactivities. Conclusions: Extracts of beetroot and onions can be used to treat Candida albicans. Conclusions: The antifungals nystatin, miconazol, and clotremazol as well as beetroot and onion demonstrated the best efficacy against Candida albicans at 95/5, 50/50, and 75/25, respectively.

Mushrooms have been used as food for centuries because of their unique taste, in addition to their great nutritional value, as it was found that there are many nutritional and medical benefits due to human consumption of mushrooms, both wild and cultivated. Nutritionally, mushrooms are rich in proteins, carbohydrates and fibers and are also low in energy and fats. It also contains a large variety of nutrients and minerals such as potassium, copper and vitamins such as riboflavin, niacin and folate. Most types of mushrooms are an important source of active compounds with the potential for medicinal and therapeutic effects. Biologically of potential medical importance, as the results of studies showed that the bioactive components isolated from mushrooms have pharmacological effects such as antitumor, antioxidant, antiviral, cholesterol-lowering, as well as lowering blood sugar effects in patients. Consuming mushrooms or one of their products in our daily diet may provide many health benefits.

When under stress, our body reacts by releasing hormones and triggering the nervous system. The hypothalamic-pituitary-adrenal axis, which transmits the stress response, is in charge of the neuroendocrine adaptation of the stress response. Corticotrophin releasing hormone neurons control hypothalamic-pituitary-adrenal function. Increased. Many metabolic and neurological problems linked to stress are associated with the synthesis of corticotrophin releasing hormone. Gamma-aminobutyric acid (GABA) and GABAergic inhibition both play a significant role in controlling the activity of CRH neurons. Several synthetic medicines that target the GABAa receptor and activate GABAa activity are used to lessen the effects of stress. These treatments have relaxing effects but also come with a variety of negative effects. As they have no adverse effects and are harmless, anti-stress herbs are utilised as an alternative therapy to help the adrenal system. Spirulina platensis (commonly referred to as ‘Spirulina’), are well for their Immune system modulation; anti-viral activity; cancer preventive properties, and cardiovascular benefits. In present work an attempt had been made to evaluate the anti-stress potential of active constituent of spirulina by molecular docking.

Every third person in the world has an inflammatory condition, which can strike at any stage of life. Inflammation is a fairly prevalent disease. Inflammation can be treated in a variety of ways. There are many medications on the market that are connected to the allopathic medical system. Herbal medications have a higher market value since they have fewer adverse effects and are less harmful. Due to their excellent nutritional and health benefits, the fruits of the Ziziphus jujuba tree, also known as jujube, red dates, or Chinese dates, are consumed as food both fresh and dried around the world. The pharmacological properties of jujube fruits, including their anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, gastrointestinal protective, and suppression of foam cell formation in macrophages, have been shed some light by recent phytochemical investigations. The goal of the current study was to evaluate Ziziphus jujube hydroethanolic extract's anti-inflammatory potential.

Crosslinked polymer networks known as hydrogels are capable of absorbing large volumes of water liquids. Depending on whether the crosslink connections are chemical or physical, hydrogels can be categorised into two groups. Physical networks feature temporary junctions that result from either polymer chain entanglements or physical interactions like ionic contacts, hydrogen bonds, or hydrophobic interactions, as opposed to chemically crosslinked networks, which have permanent junctions. Swellable polymeric polymers called hydrogels have received a lot of attention as potential drug delivery system carriers. These biomaterials have drawn attention because of their unusual properties, such as swelling in aqueous media, sensitivity to pH and temperature, or sensitivity to other stimuli. Because they are made of biocompatible materials, hydrogels are known to protect drugs from the in vivo environment, particularly peptides and proteins. Moreover, these swelling polymers are useful as tissue-specific targetable carriers for bioactive medicines. This article provides a summary of the developments in hydrogel-based drug delivery that have captured the attention of the majority of researchers.

The perennial plant Tridax Procumbens is particularly intriguing, and its secondary metabolites, also known as T. procumbens flavonoids (TPFs), are well-known phytochemical agents due to their diverse medicinal uses, including their anti-inflammatory, anti-anemic, and anti-diabetic effects. The antipyretic potential of luteolin, a natural product isolated from the medicinal plant Tridax procumbens, was investigated for antipyretic action through molecular docking analyses with the target enzymes cyclooxygenase-2 (COX-2). The docking result of luteolin revealed that their docking scores was -7.24 kcal mol–1 and it can be predicted as good inhibitor of human COX2 receptor.