The present study was designed to describe of the morphological, histological, and immunohistochemical changes of the testis in local male rabbits (Oryctolagus cuniculus) postnatal period at age immature (45day), and mature(150day) with special emphasis on immunohistochemical-related components. This study was investigated to study the development of testis during postnatal periods. Thirty of male rabbit (Oryctolagus cuniculus) of postnatal period in two age (45 days immature and 150 days mature), were used in this study. Samples were collected by purchasing them from veterinary clinics. They were admitted to the university (Al - Qasim Green University) animal house and monitored for good health for 15 days. Morphological study10 rabbits, histological study 10 rabbits and immunohistochemistry 10rabbits (5for each age). The rabbits were then placed on the dissection stage after anesthesia. The weights of the rabbits were measured using an electronic balance. The rabbits were in good health, and the testicles were cut in the perineum after dissection. nAt age immature (45 day) the testis of male rabbits (Oryctolagus cuniculus) showed that located intra-abdominally on both sides near the kidneys, and the scrotum was not clearly developed. The testes appeared curved and elongated in shape with a dark brown coloration. Morphometrically, differences were observed between the left and right testes. The mean weight of the left testis was low with noticeable variation, while the right testis showed a lower mean weight with slight variation. The mean length of the left testis was greater with small variation, compared with a shorter length with small variation for the right testis. The mean width was larger with minimal variation for the left testis and smaller with minimal variation for the right testis.