Infectious mononucleosis (IM) or Mononucleosis syndrome is caused by an acute infection of Epstein-Barr virus (EBV). This study was aimed at determining the levels of haemoglobin, total white blood cell (TWBC) count, neutrophils, lymphocytes, monocytes and eosinophils in patients infected with infectious mononucleosis at Federal Teaching Hospital, Owerri. A total of sixty subjects (30 patients and 30 controls) were enrolled in the study after giving their informed consent and completing questionnaires. The procedure was carried out at Federal Teaching Hospital, Owerri. Five millilitres of venous blood sample was collected at the ante-cubital vein aseptically and was dispensed into ethylenediaminetetraacetic acid (EDTA) containers. The EDTA containers were properly labeled with the subject’s name, sample number and date of collection. Haemoglobin was determined using the cyanmethaemoglobin method, TWBC was determined using the improved Neubauer counting chamber, while the differential count was determined using Romanowsky staining method. Data generated were analyzed using SPSS version 27, and mean, standard deviation, t-test, correlation and p-value were determined. The mean values of haemoglobin (8.9±1.44)g/dl and neutrophils (28.53±12.77)%, were significantly reduced in patients with infectious mononucleosis when compared to the controls (12.83±1.34)g/dl and (54.27±10.20 ((p=0.000 and p=0.001)) The mean values of TWBC (17.66±8.54)%, lymphocytes (59.87±13.14)% and monocytes (10.30±6.68)%)% were significantly increased in patients with infectious mononucleosis when compared to the controls (6.17±2.53)%, (49.23±13.57)% and (5.93±2.91)% ) respectively (p=0.000, p=0.003 and p=0.002). There was no significant difference in the mean value of eosinophil count in infectious mononucleosis (1.30±1.56)% (p=0.784) when compared to the controls (1.20±1.24)%. There were no significant differences in the mean values of haemoglobin, TWBC, neutrophil, lymphocyte, monocyte and eosinophil counts in male patients with infectious mononucleosis (9.14±1.52)g/dl, (19.16±9.36)x109/L, (27.69±11.18)%, (59.44±11.17), (10.13±6.12)% and (1.44±1.89)% when compared to the female patients (8.82±1.38)g/dl, (15.94±7.46)x109/L, (29.50±14.38)%, (60.36±15.51)%, (10.50±7.50)% and (1.14±1.09)% (p=0.568, p=0.311, p=0.705, p=0.852, p=0.881 and p=0.614). There was a non-significant positive correlation of haemoglobin with TWBC, neutrophils, lymphocytes, monocytes and eosinophils in infectious mononucleosis patients (r=0.17, p=0.357; r=0.15, p=0.421, r=0.07, p=0.730, r=0.11, p=0.563 and r=0.06, p=0.751). In conclusion, the data in the present study showed that infectious mononucleosis is characterized by increase in lymphocytes and monocytes with decreased levels of haemoglobin and neutrophils. Haemoglobin concentration does not have any relationship with white blood cells in patients with infectious mononucleosis. In the management and treatment of patients with infectious mononucleosis, complete blood count should be incorporated as a routine test, so as to aid in the diagnosis.

Today human mankind stands in the middle of deep scientific understanding of United Nations and Global Sustainable Development Goals. In the similar vision, medical science and health science perspectives are in the middle of scientific rejuvenation and scientific steadfastness. Schizophrenia is an extremely difficult ailment to treat. The author is suffering from schizophrenia since November,1993. He is diagnosed with glaucoma in his right eye since October, 2012. Today he is beset and replete with different symptoms of schizophrenia. Long years of illness has passed since 1993. Science and technology today has no answers towards the cure and treatment of schizophrenia. The author in this article elucidates with cogent and lucid insight his medical diagnosis of the treatment of schizophrenia and the immense trials and tribulations in his life. With immense agony and pain, the author depicts profoundly the needs of psychological and psychiatric help in the treatment and cure of schizophrenia.

The various demands that are placed on students by both internal and external sources have resulted in stress in their academic lives. Teenagers are particularly vulnerable to the problems associated with academic stress because they are adapting to both personal and cultural changes. Thus, it is crucial to comprehend the origins and consequences of academic stress to create efficient intervention strategies. The study's quantitative research approach included the use of the Academic [5]. Stress Scale to identify participants from four streams: commerce, management, humanities, and basic sciences. Five features of sources were further examined: insufficient study facilities, teacher-student connections, interpersonal difficulties with teachers, fear of failure, and personal inadequacy. Additionally, gender differences were found. School psychologists and counselors could create more effective counseling modules and intervention tactics to help pupils cope with stress if they had a better understanding of the causes of stress [6].

Background and objective: The study of the S1P signaling pathway in the context of diabetes offers a novel perspective for understanding the mechanisms underlying cognitive decline and developing new therapeutic strategies. Material and methods: The study involved 24 Wistar rats, divided into three groups: group 1 was given distilled water and served as a control group; group 2 was made up of rats made diabetic and given distilled water; group 3 was made up of rats made diabetic and treated with D-erythro-dihydrosphingosine (SPK1 and SPK2 inhibitor). Behavioral tests included object recognition and maze tests, and Rt-PCR was used to assess sphingosine-1-phosphate expression. Results: The study revealed significant differences in weight between rats, with a notable decrease observed from day 7 onwards. It also revealed significant differences in the time spent exploring objects and the mental influence of diabetes on the acquisition of spatial knowledge. The study also revealed that diabetes affects working memory and inhibits S1P expression in the hippocampal region. Conclusion: The study reveals significant differences in exploratory behavior and memory capacity between diabetic and normal rats, highlighting the negative effects of diabetes on memory.

Medical education is highly demanding, with students facing intense academic, emotional, and professional challenges. First-year students face the pressures of adjusting to a rigorous curriculum and new social environments, while final-year students experience heightened stress related to career uncertainty and impending clinical responsibilities. Understanding the sources of stress and coping strategies at different stages of training is crucial for developing targeted interventions that promote student well-being and academic success. Hence, this study aimed to assess the differences in perceived stress sources and coping strategies among first and final-year undergraduate medical students using an online survey. Sociodemographic information was collected, and stress levels were measured using the Perceived Stress Scale, while sources of stress were identified with the Medical Student Stressor Questionnaire. Coping strategies were evaluated using the Brief-COPE. Statistical analysis was performed using SPSS, with Chi-square tests to compare groups. A total of 264 medical students (132 first-year, 132 final-year) participated in the study. First-year students reported higher levels of stress, with 84.8% experiencing moderate stress, while final-year students showed more balanced stress distribution. Academic, interpersonal, and teaching-related stressors were most significant. First-year students predominantly used problem-focused coping, whereas final-year students employed more emotion-focused and avoidant coping strategies, with significant differences observed between the cohorts. Our results highlight the evolving stress experiences and coping strategies across the medical curriculum, underscoring the need for targeted mental health support that promote student well-being.

Science, civilization and mankind are today in the path of newer scientific divination as regards application of neuroscience and neuro-engineering in diverse areas of science and technology. Neuroengineering is the agglomeration of neuroscience, experimental neuroscience, computational neuroscience, neurology, electrical engineering and nanotechnology. The scientific frontier of neuro-engineering needs to be envisioned and revamped with the passage of scientific history and time. Scientific provenance, scientific divination and scientific revelation are the key highlights of neuroengineering, neuroscience and electrical engineering science today. Today the science of psychiatry and psychology are merged with neuroengineering and neuroscience. The author is a schizophrenic patient since November,2023. From October 2012, he is diagnosed with glaucoma in his both eyes. In this article, the author deeply and profoundly highlights the lucid and insightful world of neuroengineering and the science of psychiatry. This article is targeted towards a newer world in the field of neuroengineering with a deep interface with the trials and tribulations in his life as regards treatment of schizophrenia.

Individual representations of trust are deeply rooted in individual consciousness and serve as significant cognitive constraints, influenced by neural processes and psychiatric factors. This paper aims to highlight the often overlooked or under-operationalized role of human trust's biological agency within the context of organizational learning. From a psychiatric and neuroscience perspective, the paper proposes that through intentional management practices, the biological agency of trust, mediated by neural mechanisms, can act as a proxy for organizational learning. It suggests that adopting a more scientific approach to management, informed by an understanding of neural and psychiatric underpinnings, can enhance employee trust from a biological standpoint, thereby optimizing human potential. This paper contributes to the literature by exploring the rarely examined intersection of human biology, neuroscience, and organizational learning, offering new insights into their combined impact.