One of the most typical malignancies in males is prostate cancer, and its global burden is increasing. Using text-mining technology, this study seeks to pinpoint important genes and biochemical processes related to prostate cancer. Using certain terms related to gene expression, PUBMED abstracts of interest were found. The extracted abstracts included gene pairings and functional connections. On the genes identified from the function interactions, biological procedures enrichment, network analysis, and gene prioritizing utilizing edge centrality of betweenness were carried out. For the modules containing at least five genes, which were retrieved from the network analysis, gene clustering and pathway enrichment analyses were built. The biological functions of the newly identified genes showed that they were involved in positive transcriptional regulation from the RNA polymerase II promoter, positive regulation of cell proliferation, and drug responsiveness. The prostate cancer enrichment analysis processes revealed that the NF signalling pathway, PI3k-Art signalling pathway, thyroid hormone signalling, and ErbB signalling pathways were enriched. According to the network analysis results, which were further sorted by their values for degree of between-ness, it was discovered that AKT1, AR, and KDM3A were the important genes. In conclusion, by concentrating on the discovered hub genes, prostate cancer can be medically treated.

Nipah virus disease outbreak occurred in Kerala in the month of May 2018. It happened in Kerala again in September 2023. As on 13th September 2023, two unnatural deaths from Kozhikode district were suspected to be due to Nipah virus infection. Again in Sept 14, 2023, TOI reports that Kerala reported its 5th case. In the absence of a definitive cure for this viral disease, the article peeps through the homoeopathic lens & explores what it can offer to deal with this viral episode. The success of homoeopathy in COVID 19 again reiterates the fact that as homoeopathy was & is effective against viral infections; it is effective against Nipah virus disease also [2]. Nipah virus is an enveloped RNA virus that has been a major cause of encephalitis outbreaks with high mortality primarily in the Indo-Bangladesh regions. The first breakout was in Malaysia-Singapore that was related to contact with pigs & the outbreak in Phillipines associated with horse slaughter. Most other out breaks has affected the Indo- Bangladesh regions. Here, the outbreaks were associated with consumption of raw date palm sap contaminated by fruit bats & had a very high secondary attack rate [3].

In arid and semi-arid regions around the world, water quality is essential in agricultural systems. The present study was evaluated Tigris River for suitability irrigation in Salah Al-Din province. Water samples were collected and analyzed for various Hydro-chemical parameters like EC, TDS, pH, total hardness (TH), Ca2+, Mg2+, CO32-, HCO3-, Cl-, SO42-, Na+, and K+, with different Irrigation indices such as Sodium percentage (Na%), Sodium adsorption ratio (SAR), Residual Sodium Carbonate (RSC), Permeability Index (PI), Kelly's Ratio (KR), Potential salinity (PS) and Hardness were also calculated. The Na%, SAR, RSC, PI, KR, PS and total hardness varied from 2.26 to 10.06 (mmol. l-1)1/2, 0.01 to 6.10 0 meq. ll-, 8.83 to 77.10%, 0.19 to 1.19 meq. ll, 1.00 to 15.16 meq. ll and 49.3 to 197.1 mg. L-1, respectively. Hence, the various parameters and indices results were concluded that the Tigris River quality was suitable to be used as a water source for irrigation. A strategic plan and regular monitoring are required to limit or reduce the pollution of the river water in order to improve the water quality in its natural condition.

It is clear from this study the prevalence of Staphylococcus aureus resistant to methicillin and Staphylococcus aureus resistant to vancomycin in different regions of Iraq. According to this study, which was conducted in the Iraqi city of Tikrit, on 285 samples, 131 of them were infected with various bacterial infections, of whom only 80% were infected with S. aureus bacteria. According to the chemical tests, including the DNA test (PCR) for the Staphylococcus bacteria isolates, the sensitivity of the isolates under study against a group of different antibiotics was tested by using the disc diffusion method. Gentamicin and Chloramphenicol (30, 28, 23, 22, and 21 mm), respectively, for all samples under study, while the percentage of bacteria resistance to Methicillin was 100%, while the percentage of Staphylococcus resistance to Vancomycin was 70% for all samples under study, where it was recorded The rate of inhibition reached (13 mm). As a result of the investigation on resistance genes, it was found that most of the virulence genes are present in methicillin-resistant samples, while the virulence genes in the Vancomycin-resistant samples recorded two types of genes, namely (Van A) and (Van B), which are responsible for building the cell wall protein. A) In samples isolated from bacterial strains, the percentages of (Van B) gene were higher. By conducting a comparison with some studies in some Iraqi cities, it was found that 71% of the isolates were resistant to Vancomycin in the city of Hilla out of a total of 200 infected isolates, and the city of Baghdad recorded infections estimated at 66.6% resistant to Vancomycin out of a total of 250 infected samples. 50% of the 20 samples infected with S. aureus, Finally, the city of Kirkuk recorded a percentage of Vancomycin resistance to isolates of S. aureus bacteria 100%, and it is also clear that all isolates in all Iraqi cities were 100% Methacillin resistant.

The purpose of this study was to describe the cognitive status of teachers who are still actively teaching and who have retired. The research method used is descriptive quantitative. The research site is SMP N 1 Bantul. Research respondents are teachers who are still teaching at SMP N 1 Bantul and who have retired from SMP N 1 Bantul. The technique of determining the sample using random. This research instrument uses the MMSE that has been provided. The result of this study is to have an overview of the distribution of teacher respondents based on cognitive status who are still actively teaching and have retired that the largest number is retired with the definitive category of cognitive impairment as many as 30 people (41%), the category of possible cognitive impairment as many as 19 people (26%) , and the normal category as many as 25 people (34%).

The article examines the contribution of real-time three-dimensional transesophageal echocardiography (3D TEE) in the assessment of ostium secundum atrial septal defects (ASD) in adults. 3D TEE provides a precise and comprehensive view of cardiac anatomy, enabling the evaluation of size, shape, and border quality of the ASD. In a series of 27 cases, 3D TEE demonstrated a strong correlation between 3D-measured ASD parameters and the size of the closure device required. This technique is crucial for accurate pre-interventional evaluation, enhancing the success and safety of percutaneous or surgical interventions for ostium secundum ASD. Three-dimensional transesophageal echocardiography represents a significant advancement in cardiovascular imaging for complex structural heart abnormalities.

COVID-19 pandemic is over now and we are in great peace of relief after three years. This pandemic has observed significant impact on quality of life globally and the put unforgettable imprints on history of mankind. Reason for more havoc in this pandemic was less studied virus by medical scientists regarding its pathophysiology, available treatment options and lack of effective vaccine to tackle this dragon. COVID-19 is the first observed and reported pandemic of corona virus related global disease apart from its previous SARS and MERS. Fast track developments in medical treatment options due to this ultrafast digital and artificial intelligence techniques have curtailed mortality on large scale globally. Although mortality is significantly reduced, morbidity is documented on a large scale worldwide in this pandemic. Morbidity due to COVID-19 now called as ‘Long COVID’, which is underreported & half-heartedly evaluated globally. Long COVID is related to persistent immune dysregulation occurs during evolution of COVID-19 as natural trend of disease. Immune dysregulation has documented during course of active viremia, during recovery of viral illness and after post viral phase. Immune dysregulation occurs in ‘selected group’ of cases irrespective of disease severity and vaccination status and observed in cases with negligible illness to advanced one mandates further research. Thus, Immune dysregulation in COVID-19 is predominant cause for long covid and leading to brainstorming effect on medical scientists and researchers as of today. Globally, one third of recovered or affected cases of COVID-19 are facing long covid and needs prompt treatment options to tackle this dragon related long term effect on body. ‘Immunomodulatory’ or immunity modifying agents are the primary targets to curtail immune dysregulation and long covid. Some experts recommend ‘disease modifying agents’ to treat long covid cases. Still, many miles to go to reach to effective treatment options for long covid and we don’t have effective options for this ‘health issue of global concern’. L-Arginine is amino acid with multiple beneficial effects such as immunomodulatory effects which will regulates immunological response in inhibit dysregulated immune system additional to its universally known antioxidant, vasodilatory and regenerative and cellular proliferation effects on immune cells. These Immunomodulatory and or diseases modifying effects of L-Arginine makes it the future candidate with ‘game changer’ role for management of Long covid resulting from immune dysregulation as a core pathophysiologic pathway of this Dragon Pandemic.