Undifferentiated pleomorphic sarcoma (UPS) is a high-grade subtype of soft tissue sarcoma (STS) characterized by its aggressive clinical behavior. It typically presents as a rapidly enlarging, asymptomatic subcutaneous mass with minimal or no overlying cutaneous changes. Definitive diagnosis relies on histopathological examination and immunohistochemical analysis. Once confirmed, comprehensive staging—encompassing assessment of the primary lesion, regional lymph nodes, and potential metastatic spread—is essential. Management is generally guided by tumor staging and typically involves en-bloc surgical resection, followed by histopathological review and multidisciplinary consideration of adjuvant therapies, including radiotherapy or chemotherapy. In this report, we present the case of a 78-year-old patient with a previous diagnostic of UPS on the right pectoral area that relapsed accompanied by massive spontaneous pneumothorax and further sepsis.

Metastatic malignant melanoma is the most lethal cutaneous neoplasm, originating from melanocytes and characterized by aggressive behavior and distant dissemination via lymphatic and hematogenous routes. Risk factors include phenotypic traits, genetic mutations, and environmental exposures. Histologically, it presents with atypical melanocytes invading the dermis, often showing nuclear pleomorphism, mitoses, and ulceration. Breslow thickness is the key prognostic indicator. Management is multidisciplinary, with surgical resection as first-line when feasible. In unresectable cases, treatment is guided by molecular profiling. We present the case of a 81-year-old female with rapid progression of the disease and ganglionar metastases.

Background: Crude mortality, cause-specific mortality, and age-specific mortality rates are important measures in epidemiology to understand the frequency and causes of death within a population. Aim of the Study: This study aimed to assess crude mortality with cause and age specific mortality rates in Altarmiyah district, Iraq. Methods: This cross-sectional study included data of 1357 deaths listed in healthcare records in Altarmiyah district, Iraq in the years 2019 – 2023. Total population in the same duration was 823739. Data of the enrolled subjects was listed including age, gender, occupation, marital status, place of death and cause of death. Measurement of crude, age-specific, sex-specific and cause specific mortality rates was performed. Results: Crude mortality rate in this study in the study duration 2019-2023 equaled 1.6 per 1000 population. Most common cause of mortality was cardiovascular disease (53.13%) followed by neurological (15.84%) and respiratory diseases (12.68%). Predominant age of death was more than 60 years (72%) followed by 41 – 60 years (15%) than less than 6 years (7.6%). Gender distribution of mortality was nearly equal between males and females.

The isolate of Aspergillus flavus from the yellow corn and their products samples had the greatest quantity of aflatoxin B1 toxin, measuring 197.8 ppb, according to an analysis utilizing HPLC technology. This isolate was identified phenotypically and molecularly diagnosed and have already been officially recognized by the National Center for Biotechnology Information (NCBI, thirty female mice were experimentally injured in six groups, and each group received 0.5 lµ oral dosage administered once through a stomach tube. With six treatments toxic filtrate, G.lucidium, calcium citrate, interference of them and control without treatment alone Findings from the investigation pathological. The toxic fungus's in histopathological ability to effects. When an autopsy was performed 21 days after the injury, the inflammatory cells had infiltrated the liver tissue and caused liver tissue cross slice with a distinct histopathological, appearance these findings validated the positive and effective role that the part the test played in the therapy, as demonstrated by the return of the liver and kidney tissues to their normal, healthy states. The detrimental impact's outcomes a harmful effect was seen in female BALB/c albino laboratory mice upon isolation of toxic fungus within the organism. The mouse musculus, wherever notable alterations occurred in the lab animals' tissues subsequent to their medication administration and throughout the experiment's duration. The impact on liver enzyme levels (GPT, GOT, and ALP) with values of 145.0, 285.0and 238.0 IU/L, respectively, in comparison to the control group's values of 45.0, 190.0, and 124.0 IU/L, As opposed to the toxic fungus filtrate group, which had concentrations of 56.0. mg/dl and 1.75 mg/dl of urea and creatinine, respectively in comparision control group was 35.0 and0.6 mg/dl respectively. The results of the laboratory investigation on kidney function revealed substantial variations in the increase in these concentrations. The findings of this study demonstrated the effectiveness after using calcium citrate and G. lucidium filtrate treatments, as well as the interference between the two treatment. Additionally, the results demonstrated the anti- and beneficial effects of these interventions affecting the regular functioning and recovery of the tissues of the kidney and liver.

Congestive heart failure (CHF) represents a complex clinical syndrome which results from multiple pathophysiological mechanisms that impair cardiac function and produce systemic symptoms. This review examines all aspects of congestive heart failure development and progression through cellular and molecular and hemodynamic abnormalities. The development of CHF symptoms and multi-organ involvement results from the combined effects of neurohormonal activation and inflammation and oxidative stress and structural cardiac remodeling. The diagnostic process for CHF identification now combines clinical assessment with biomarkers and imaging techniques and hemodynamic evaluation to provide earlier and more precise diagnoses. The current treatment approaches for CHF include pharmacological neurohormonal pathway interventions and lifestyle changes and device-based therapies and surgical procedures that match disease severity and patient characteristics. The development of gene and cell-based treatments together with precision medicine and artificial intelligence applications shows promise for better patient outcomes. The implementation of pathophysiological knowledge in clinical practice through personalized and team-based care approaches leads to the best possible management outcomes. The review emphasizes ongoing challenges and future directions in CHF research and treatment because continued innovation remains essential to decrease the worldwide impact of this common disease.

Herpes simplex virus type 1 (HSV-1) is a common neurotropic virus that remains latent in sensory neurons after the initial infection. Reactivation can occur throughout life, especially in the presence of triggering factors such as trauma, immunosuppression, or stress. We present a case of a 72-year-old male developed herpetic stomatitis with perioral vesicular lesions following multiple traumatic injuries, including severe head trauma and subarachnoid hemorrhage.

Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis that primarily affects superficial postcapillary venules. Histopathological examination reveals predominantly neutrophilic inflammation along with leukocytoclasia. The exact incidence of LCV is not fully understood. Clinically, LCV typically manifests as palpable purpura that can appear anywhere on the body, although it frequently affects the lower limbs. It can develop at any age, but it is more frequent in adults. LCV may be triggered by various factors, including infections, autoimmune disorders, neoplasms, or medications; in some cases, it may be idiopathic, accounting for up to half of all instances. Typically, the condition is mild to moderate, some patients may be asymptomatic, and can improve with supportive care measures. Diagnosis is made through clinical assessment, laboratory tests, and skin biopsy. Treatment should be dictated according to the etiology and most of the cases is symptomatic. We present the case of a 55-year-old woman with autoimmune conditions who presented with abdominal pain and disseminated palpable purpura.