The aim of the current study was investigating the antiatherogenic effects of olive oil and gallic acid as a combination. Forty male atherogenic rats were arbitrary divided into five groups (n=8), 1 was given 1ml distilled water as control group (G1), while the groups G2, G3, were drenched 1ml of olive oil and 100mg/kg.bw of Gallic acid respectively. As well as G4 was given 40mg/kg.bw of Atorvastatin and G5 used as a combination group drenched with the same dose of G2 and G3 together for 30 consecutive days. The higher body weight of experimental study rats at zero time was (162±4.05g) on average in gallic acid group. All the atherosclerosis induced rats demonstrated suppression of increase in body weight as compared to the control positive group which reported the high body weight (329±5.09g). The significant (P < 0.05) suppressions of body weight gain in atherogenic rats treated with Atorvastatin was observed at the end of the study as compared to the body weight of those in G1, G2, G3 and G5 respectively. Moreover, the results of the Nitric oxide (NO) revealed there was a significant difference (P<0.05) in all experimental groups after treatment. The highest means were shown in G4 (41.61 µmol/L) and G5(33.50 µmol/L) with non-significant difference between them, followed by G3 (23.92 µmol/L) which was significantly (P<0.05) lower than G4 and G5, but significantly (P<0.05) respectively. In the same line the histopathological section Aorta of control positive rats showed moderate to severe atherosclerosis was seen in the affected aorta wall, with three plaques with thickening of aorta wall. Alos, the aggregation of Atheroemboli that occupied 35% of lumen area of the affected aorta. While there was mild atherosclerosis was seen in the affected aorta wall. Note two mild atherosclerosis plaques, were observed as abnormal thickening in the affected aorta wall of Atorvastatin and combination group respectively. In conclusion, the results indicate that Olive oil and Gallic acid showed potential antiatherogenic effects but may require additional exploration to maximize their therapeutic benefits.

N/A

Introduction: The Sella Turcica (ST) is a saddle-shaped structure in the sphenoid bone, and it houses the pituitary gland within the pituitary fossa. The primary imaging technique for studying the morphometry of the ST is computed tomography (CT). The purpose of this study is to measure the dimensions of ST and their relationship with age and gender in Libyan subjects who live in Benghazi using CT scans. Material and method: A cross-sectional study was carried out from September 2023 to December 2024. The information was collected from 181 randomly chosen head CT scans of patients who came to the Benghazi Medical Center (BMC) and Aljalla Teaching Hospital. Patients are male and female Libyan patients (67 women and 114 men) aged 18 and above. Two calibrated examiners examined each scan. The data collected was analyzed statistically, and results were obtained. Results: The study sample included 181 participants, with 63% being male (114) and 37% female (67). Participants were divided into four age groups: Group I (ages 18-30, 17.1%, n=31), Group II (ages 31-40, 16.6%, n=30), Group III (ages 41-50, 17.7%, n=32), and Group IV (ages over 50, 48.6%, n=88). The average measurements of the sella turcica in the study group were 10.7 mm in length, 8.7 mm in depth, and 12.9 mm in AP diameter. For male participants, the measurements were 10.8 mm in length, 8.62 mm in depth, and 13.00 mm in AP diameter. For female participants, the measurements were 10.5 mm in length, 8.73 mm in depth, and 12.7 mm in AP diameter. No significant difference in sella turcica dimensions was found between genders (p > 0.05). However, there was a significant difference in mean sella length and AP diameter across the four age groups. This was mainly due to Group I (ages 18-30) having a smaller mean sella length (9.7 mm) and AP diameter (12.1 mm) compared to the other age groups. There was no significant difference in sella depth among the age groups. Conclusion: The findings of this research could have important clinical implications for surgeons and medical professionals. Increased understanding of potential anatomical variations in the sella turcica may impact surgical planning and patient outcomes. Additionally, this study is expected to be a reference for future research studies related to neuroanatomy, contributing to advancing diagnostic techniques, treatment options, and overall patient care in Benghazi.

This investigation looked at the impacts of okra seed extract on cholesterol-induced fatty liver disease (CIFLD) in rats. In this study, thirty-two male rats were divided into four groups: G1 the control group, G2 cholesterol group, G3 300 mg/kg of cholesterol plus okra extract and G4 400 mg/kg of cholesterol plus okra extract. Four weeks post-experiment, blood samples were collected for lipid levels, oxidative stress indicators, and liver function tests. Table 1 shows the serum level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), which was significantly reduced in the okra extract treatment group (ALT: 200 mg/kg, 100.3 ± 8.6 U/l, 400 mg/kg, 70.5 ± 6.2 U/l), compared to the cholesterol group (ALT: 150.5 ± 10.4 U/l; AST: 120.3 ± 8.6 U/l). TG and TC levels were higher in cholesterol group (TG 150.5 ± 10.4 mg/dl; TC 200.3 ± 8.6 mg/dl) but significantly (P < 0.0001) lower (TG 100.3 ± 8.6 mg/dl and 70.5 ± 6.2 mg/dl for 200 mg/kg and 400 mg/kg respectively) in okra extract treated groups. Cholesterol group showed significantly (p < 0.01) higher malondialdehyde (MDA) (6.5 ± 0.3 nmol/ml) level, less superoxide dismutase (SOD) (3.2 ± 0.4 U/ml) and less glutathione (GSH) (1.5 ± 0.2 μmol/g tissue) than normal, which were all significantly (p < 0.01) improved by okra extract treatment (400 mg/kg) (MDA: 2.8 ± 0.2 nmol/ml, SOD: 7.0 ± 0.4 U/ml, GSH: 4.8 ± 0.3 μmol/ml). Histopathological analysis showed that severe steatosis and signs of inflammation observed in the cholesterol group were significantly less pronounced on okra-treated groups. We demonstrated that okra seed extract exhibited an effective hepatoprotective properties, which may be, at least in part, through antioxidant properties, the results of this study suggest that okra seed extract seen as a natural treatment option for fatty liver disease.

Background: Breast cancer is the leading cause of cancer-related mortality among women worldwide. Platelet indices and serum iron have been implicated in cancer pathophysiology and may serve as potential biomarkers in breast cancer. Objective: This study aimed to evaluate the levels of platelet indices and serum iron in breast cancer patients attending Imo Specialist Hospital, Owerri, Nigeria. Methods: A total of 60 subjects, comprising 30 breast cancer patients and 30 apparently healthy controls, were recruited for this cross-sectional study. Ethical approval was obtained, and informed consent was secured from all participants. Structured questionnaires were administered to gather socio-demographic and clinical data. Six (6) mL of venous blood was collected from each participant; 2mL was dispensed into ethylenediaminetetraacetic acid (EDTA) containers for platelet indices determination using an autoanalyzer, and 4 mL into plain tubes for serum separation and iron analysis using spectrophotometry. Data was analyzed using SPSS version 27, with mean, standard deviation, Student's t-test, Pearson correlation, and p-values determined. Results: The mean values of mean platelet volume (MPV), platelet distribution width (PDW), and serum iron were significantly higher in breast cancer patients [(10.51±1.89) fL, (20.29±7.66) %, and (50.40±15.22) µg/dL, respectively] compared to controls [(7.81±0.46) fL, (15.33±2.89) %, and (27.13±8.45) µg/dL] with p-values of 0.000, 0.002, and 0.000, respectively. However, no significant differences were observed in plateletcrit (PCT) (0.23±0.23) % and platelet large cell ratio (P-LCR) (22.91±7.52) % in breast cancer patients when compared to controls (0.19±0.07) % and (17.59±20.09) % (p=0.338 and p=0.180]. Age-stratified analysis revealed no significant differences in MPV, PDW, PCT, P-LCR, and serum iron between breast cancer patients aged 35–50 years and those older than 50 years (p>0.05). Furthermore, there was a non-significant positive correlation between serum iron and platelet indices, including MPV (r=0.09, p=0.607), PDW (r=0.04, p=0.833), PCT (r=0.15, p=0.421), and P-LCR (r=0.19, p=0.304). Conclusion: This study shows that breast cancer is associated with significantly raised MPV, PDW, and serum iron levels, suggesting enhanced platelet activation and altered iron metabolism in affected patients. These findings imply that MPV and PDW may serve as useful markers for platelet activation, tumor progression, and inflammation in breast cancer. Additionally, elevated serum iron may reflect its involvement in breast cancer pathogenesis. Routine evaluation of platelet indices, particularly MPV and PDW, along with serum iron levels, should be recommended as part of the diagnostic and prognostic assessment of breast cancer patients. Further large-scale studies are warranted to validate the utility of these parameters as biomarkers for breast cancer progression and therapeutic monitoring.

Abstract: Introduction: Thyroid infections are rare clinical situations. These include acute suppurative thyroiditis (AST), including abscesses, where the most common infectious agents are gram-positive cocci, thyroid abscesses caused by gram-negative aerobes are rare, as is the case with salmonella. Case Report: We report a case of 50 years old female patient who presented with a painful cervical swelling, evolving since2 weeks, diagnosed as thyroid abscess due to salmonella enterica which revealed a previously undiagnosed diabetes. The abscess was treated by surgical drainage with double systemic antibiotic therapy. Discussion and conclusion: Thyroid abscesses are rare, and salmonella bacteria are an exceptional cause. This type of infection is favored by situations of immunodepression, such as diabetes, especially if undiagnosed or untreated.

The teaching of macroscopic anatomy has changed a lot from ancient times until now, since the first human being observed the anatomical parts of other human beings or animals either during a healing action, a fight or a hunting. Later on the first documented systematic anatomical dissections on the human body were carried out around the third century B.C. in Alexandria, but soon was banned for about 16 centuries. Anatomical dissections were restored during late middle age and subsequently improved during the renaissance and following centuries. In the 21st century as complement to improve the medical education new technologies to the teaching of human anatomy are being incorporated. Nevertheless, anatomical dissection will continue to be essential in medical education because cadavers impart a real-time three-dimensional perspective about human body complexities and improve medical practical skills.