South Asian Res J Pharm Sci | Pages : 48-53
DOI : 10.36346/sarjps.2022.v04i03.001
The present study was undertaken to investigate the learning and memory enhancing activity of Cucurbita pepo seed extract in rats by using the ethanol induced cognitive impairment and its effects were examined by using 8-radial arm maze (8-RAM) test. For radial arm maze test all groups showed significantly (P value is< 0.0001& < 0.001) decreased in the time taken to reach the paired arm and number of entries in baited arm and non-baited arm as compared to ethanol inducing group. Therefore seed extracts of Cucurbita pepo exhibited significantly learning and memory activity in Alzheimer’s disease.
Talib Wseen Hussein, Khalil Ismail Abid Mohammed, Mohammed Abdul Salam
South Asian Res J Pharm Sci | Pages : 54-59
DOI : 10.36346/sarjps.2022.v04i03.002
The study was carried out to detection of Toxoplasma gondii in (135) women patients with repeated abortion with age ranged 18-43 years who attended two teaching hospitals in Baghdad. The diagnosis is done by Immunochromatography and ELISA methods. a blood samples was taken from each patients as well as other(30)healthy control matching in age. The study included measurement the concentration of Interleukin-6, Interleukin-17, Dopamine and Complement in sera of patients and control .The result indicated presence the of anti-Toxoplasma IgG in 26 cases a, Anti-toxoplasma IgM in 14 cases and 10 in both out of 135 cases of aborted women with Toxoplasma in immunochromatography methods while the level of IgM 1.57 IU/ml and IgG 142.73. Also, the result indicated significant increasing levels of IL-6 and IL-17, Complement and Dopamine in patients sera in comparison with healthy control.
Firas Nabeeh Jaafar, Majid Ahmed AL-Bayati, Hadeel Kareem Musafer, Maan Abdul Azeez, Zahraa Kareem Raheem
South Asian Res J Pharm Sci | Pages : 60-69
DOI : 10.36346/sarjps.2022.v04i03.003
Quorum sensing (QS) is cell to cell signaling mechanism that enables bacteria collectively control gene expression in response to their population density, or it is bacterial communicate with one another using chemical signals. There are three types of signaling molecules: Acyl-homoserinelactonase (AHLs), Auto-inducer peptides (AIPs) and Autoinducer-2 (AI-2). Q.S was first observed and described in bioluminescence bacterium V.fischeri.In V. fischeri, several kinds of quorum sensing system were identified. At first, lux system was found and regulates the luciferase operon and light production. LuxIwas isolated as an AHL synthase while LuxR was isolated as a transcriptional activator of the luciferase operon. At low cell density, LuxOrepresses LitR, which is a positive regulator of the expression of LuxR. Quorum quenching (QQ) refers to the mechanism by which bacterial communication can be interrupted, or it is the process of preventing QS by disrupting the signaling.The first major QS-disrupting strategy that has been studied is the interference with the detection of the AIs and the second one is the inactivation/degradations of the signal molecules.
Eslam Abdalla Mohammed Ahmed, Mohammed Osman Ali, Lana Jamal Abubaker, Ghanem Mohammed Mahjaf, Hamza Ahmed Hassan, Mosab Nouraldein Mohammed Hamad
South Asian Res J Pharm Sci | Pages : 70-74
DOI : 10.36346/sarjps.2022.v04i03.004
Background: Covid-19 vaccine is an immunization method used to reduce coronavirus incidence but lately caused life-threatening events such as thrombosis with thrombocytopenia syndrome. Methods: This is a case-control study conducted at Shendi town to evaluate platelet parameters and fibrinogen levels in vaccinated healthy individuals With Covid-19 vaccines between Augusts to November 2021. A total of (100) vaccinated healthy individual With the Covid-19 vaccine was enrolled in the study as test groups, compared with (50) healthy volunteers as a control group. Venous blood samples were transferred into Trisodium citrate and EDTA anticoagulant. Data was collected using a questionnaire and the (SPSS) version (22) program was used for data analysis. Results: The study revealed that the vaccinated healthy individuals were; (50%) male and (50%) female. The platelets parameter and fibrinogen indicated the mean values of platelets count, mean platelets volume, platelets distribution width, platelet crit, and fibrinogen, in Janssen vaccine groups, were (251.14 109\L), (8.39 fl), (15.6), (0.203%), and (158 mg\dl) respectively. The results study revealed the mean of PLT, MPV, PDW, PCT, and Fibrinogen, in Astrazeneca vaccine groups, were (272.08 109\L), (8.13fl), (15.56), (0.2211%), (159 mg/dl) respectively. Also explained the mean of PLT, MPV, PDW, PCT and Fibrinogen, in Astrazeneca vaccine groups were (272.08 109\L), (8.13fl), (15.56), (0.2211%), (159 mg\dl) respectively and in Janssen vaccine groups the mean values of PLT, MPV, PDW, PCT, Fibrinogen were ( 251.14 109\L), (8.39fl), (15.63), (0.2034%), (158 mg\dl) respectively. Conclusions: Covid-19 vaccines are responsible for significant changes in fibrinogen level in both AstraZeneca and Janssen vaccine groups.
Professor Aamir Abdullahi Hamza
Editor-in-Chief "South Asian Research Journal of Medical sciences"
Dr. Mohamad Fazli Sabri
Editor-in-Chief "South Asian Research Journal of Business and Management"
Dr. Fatmir Shehu
Editor-in-Chief "South Asian Research Journal of Humanities and Social Sciences"
Dr. Sunil Kumar
Editor-in-Chief "South Asian Research Journal of Agriculture and Fisheries"
Prof. Helme Ahmed Altaee
Editor-in-Chief "South Asian Research Journal of Oral and Dental Sciences"
Dr. Md. Habibur Rahman
Editor-in-Chief "South Asian Research Journal of Pharmaceutical Sciences"
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