Liver abscess is a rare condition that can be divided into amoebic liver abscess and pyogenic liver abscess. The diagnosis is confirmed by performing an ultrasound or computerized tomography. The management of liver abscesses has seen a trend toward minimally invasive procedures like percutaneous drainage and intravenous antibiotics. Percutaneous drainage can be divided into percutaneous catheter drainage and percutaneous aspiration. Surgical drainage can be divided into open and laparoscopic drainage. In this chapter, we will look at the management of liver abscesses, especially the role of percutaneous drainage, which includes percutaneous catheter drainage, percutaneous aspiration, and surgical drainage.