Rice not only an essential food but also a source of protein. Ancient Ayurvedic Acharyas described Raktashali red rice as a nutritive food and medicine. Rice is the second most used cereals in the world next to wheat. Ayurveda have attributed some medicinal properties too in addition to main stay as food. According to Ayurveda rice has the ability to alleviate or subdue Tridoshas (humors) – Vata, Pitta and Kapha -whose imbalance causes various types of diseases within the body. Different groups of rice have different effect on human body as they have different inherent properties. From being used as a diet for sick it has been used as a wholesome and rice is considered as best food in some diseases mentioned in different Ayurveda text.

Tacrine has several mechanisms of action. The putative primary mechanism of action of tacrine for Alzheimer's disease is reversible inhibition of acetylcholinesterase (AChE), which thus slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase activity. In accumulation, tacrine blocks sodium and potassium channels. Tacrine also acts as a histamine N-methyltransferase inhibitor. This study was carried out to develop matrix based transdermal patches containing Tacrine to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. . Matrix type of transdermal patches was developed by using Methocel K4M, Methocel K15M, Methocel K100M and Xanthan gum polymers. Transdermal patches were prepared by employing solvent casting method. Drug excipients compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F16, and all the formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be within the pharmacopeial limits, invitro drug release studies by using dialysis membrane. Among all the 16 Tacrine transdermal patches formulations F5 formulations which contain Methocel K15M 100 mg had shown 97.61% % cumulative drug release within 12 hours.

The extraction of altrenogest with acetonitrile from sesame oil is not an easy task due to the formation of a stable emulsion. The problem of extracting more than 99% of altrenogest from sesame oil with acetonitrile was solved. The optimal ratio of extractant to extractor was established. This approach allowed for a quantitative analysis of altrenogest in sesame oil solutions by HPLC/MS. A generalization of the proposed approach to cases of altrenogest extraction from stable emulsions was discussed.