It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or proposed uses in medicine that are still in preclinical and clinical investigations. NAC is also used in food supplements and cosmetics. It is often used to treat an overdose of the L-amino acid molecule, which is acylated to N-acetylserotonin. Several scientific studies show that supplementation of N-acetylenene improves clinical trials show that it may help to stop exacerbation of COPD and delay or slow down the onset of contrast-induced kidney problems and help with the management of pulmonary fibrosis until it is diagnosed, as well. N-Cysteine can be used to treat H. pylori and H. pylori-align prevention in cancer treatment in patients receiving gentamicin adenoids for the prevention of hearing loss due to gentamicin dopamine administration in patients doing dialysis.

Hyperlipidemia is a disease portrayed by an extension, in any incident, one of the plasma lipids, including triglycerides, cholesterol, cholesterol esters just as plasma lipoproteins including outstandingly low thickness and low thickness lipoproteins close by diminished high thickness lipoproteins levels. This stature of plasma lipids is among the leading risk factors related to cardiovascular illnesses. The present review focuses on the sorts of hyperlipidemia, lipid processing, the pathophysiology of hyperlipidemia, treatment frameworks for raised lipid profiles. In the interim statins and fibrates remain the major antihyperlipidemic administrators for the treatment. The fortune spot of the plant domain has different plants to treat this ailment. The indigenous course of action of the drug gives bountiful data about plants available for the treatment of hyperlipidemia. The review also lightens the role of nutraceuticals in hyperlipidemia therapy. The search was performed in PubMed, PsycInfo, Web of Science, Scopus, and Medline databases. A quality assessment yielded a total of 60 papers to be considered for the review by using strict inclusion and exclusion criteria.

Triazines are a diverse class of compounds that possess three consecutively bonded nitrogen atoms. Triazenes have been utilized in a variety of research areas. In organic synthesis, they have been used as protecting groups for aromatic amines, as linkers in solid-phase peptide synthesis and as synthons for novel heterocyclic compounds. In the present research work, we synthesized a series of novel Benzothiazole derivatives and Triazene derivatives by using some sulfa drugs. The Benzothiazole derivatives such as substituted 2-amino benzothiazole synthesized by a different procedure in which some sulfa drugs were reacted with ammonium thiocynate and prepared substituted phenylthiourea. The cyclization of substituted phenylthiourea prepared in the presence of bromine solution with chloroform and then prepared Benzothiazole nucleus. Triazene derivatives such as substituted 4-[1(E)-3,3 dimethyl-1-triazen-1-yl] synthesized by a different procedure in which some sulfa drugs were reacted with dimethylamine in presence of 6M HCl and NaNO2 and then prepared substituted 3,3 dimethyl-1-triazen-1-yl. These compounds were screened for anti-inflammatory activity by carrageenan induced paw oedema method in rats at a dose of 10 mg/kg body weight.

Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as PH, ionic strength, temperature. Hydrogels are a unique class of three dimensional cross-linked polymeric networks that can hold a large fraction of aqueous solvents and biological fluids within their structures. Nowadays, hydrogels have attracted a growing interest of many scientists in different fields of research. Intelligent hydrogels have found a significant role in a wide variety of applications such as drug delivery systems, tissue engineering, optics, diagnostics and imaging. The purpose of this paper is to present a brief review on the basis concept of hydrogels, the description about classification, synthesis methods, stimulation situations, relevant mechanisms, and applications. It also involved technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process. An innovated category of recent generations of hydrogel materials was also presented in some details. The formulations obeyed Higuchi and Korsmeyer- Peppas kinetics of drug release. For further confirmation, the data were fitted to the Kopcha model to get the evidence of drug release by the combination of diffusion-controlled and chain relaxation–swelling mechanism. However, the diffusion mechanism predominated the process leading to quasi diffusion and anomalous diffusion mechanism.