A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of Domperidone and Esomeprazole. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 267 nm and 300 nm, λmax of Domperidone and Esomeprazole respectively. Beer’s law was obeyed in the concentration range of 10-50 μg/ml for Domperidone for Esomeprazole 5-25 μg/ml. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of Domperidone and Esomeprazole in combined tablets form with good accuracy and precision. The suggested methods were validated according to International Conference of Harmonization (ICH) guidelines and the results revealed that; they were precise and reproducible. All the obtained results were statistically compared with those of the reported method, where there was no significant difference.

Pyridazine and pyridazinone derivatives compounds are biologically important compounds. Pyridazinone has carbonyl group on third carbon on pyridazine ring. Pyridazine and pyridazinone is a wonder nucleus because their derivatives give amost all types of biological activities such as such as analgesic, antiinflammatory, antimicrobial, antisecretory, antiulcer, antidepressants, neuroleptics, anxiolytics, sedative, hypnotic, tranquillizer, anticonvulsant, antiplatelet, antithrombotics, anticancer, antihistamine, cardiotonics, vasodilatators, antiarrhythmics, antidiabetic, antihypertensive, antitubercular and various other types of activities. These compounds are synthesized with the aim of novel agents those possess interesting biological activities. The present review has been focused on the pyridazine and pyridazinone derivatives with potential pharmacologica activities.

Psychiatric disorders are one of the major causes of global burden of diseases. Stigma remains a major impediment in the delivery of mental healthcare. It has been found across various studies that attitudes of doctors of other specialties and other healthcare professionals also contribute to stigma due to their lack of knowledge and awareness about psychiatry and mental health problems. The number of mental health professionals remains abysmally low. Community pharmacists are accessible, knowledgeable, and capable of providing mental health promotion and care in communities. This may not be a role that is recognized by the public, and men in particular. However, psychotherapy paired with medication is the most effective way to promote recovery. Examples include: Cognitive Behavioral Therapy, Exposure Therapy, Dialectical Behavior Therapy, etc. Pharmacists can play a key role by providing mental health medication management support to improve access and address patients' mental health needs.

There are around 60 global species belonging to the genus Sesbania which are commonly found to be grown in Africa, Australia, and Asia. The leaves of Sesbania grandiflora have been used in local traditional medicine since ancient times. Major chemical constituents are alkaloids, flavonoids, glycosides, tannin, anthraquinone, steroid, pholobatannins, and terpenoids. Isovestitol, medicarpin, sativan (isoflavonoids) and betulinic acid (tannin substance) are the major constituents responsible for antibacterial and antifungal, antioxidant, anti-urolithiatic, anticonvulsant and anxiolytic, and hepatoprotective properties. Also, the plant extract contains alkaloids, phenolics, tannins, triterpenoids, and sterols. All parts of S. grandiflora are used in traditional medicine and phytochemical investigations have been conducted on extracts of the leaves, seeds and roots of S. grandiflora to provide scientific validation of its properties.

The purpose of this study was to analyse the International Commission of Radiation Unit (ICRU) point doses delivered to the urinary bladder and rectum with ultrasound based intracavitary brachytherapy and to evaluate late toxicity relative to the equivalent total doses delivered in 2 gray per fraction of equivalent dose (EQD2) for bladder and rectum using point based methods of reporting. This study was conducted using a quantitative retrospective research design which looked at three hundred and thirty three women who received external beam radiation therapy (EBRT) + brachytherapy (BT) between 2009 to 2013. The patients were aged 25 years and above the median age was 48. The median follow-up was 24 months and 58% of patients received 50 Gray in 25 fractions with 24 Gray in 3 fractions of BT and 42% received 46 Gray in 23 fractions to the pelvis with 26 Gray in 4 fractions of BT. BT was delivered with ring and tandem applicators. The results showed no correlation between late toxicity for rectum and total EQD2 to ICRU rectal points rs =0.1. For bladder the null hypothesis that there was no association between EQD2 and late toxicity grade for bladder was rejected and the alternative hypothesis that there was association between EDQ2 and late toxicity grade for bladder accepted, rs= 0.013. The mean rectal and urinary bladder doses at ICRU points were 59.8 % (4.5 Gy) and 62% (4.6 Gy) which was below the ICRU 38 recommended dose of lower than 80% of maximum dose to the rectum and bladder of the prescribed dose to point A.