Background: The aim of the study was to see the influence on the outcome of Hematopoietic Stem Cell Transplantation (HSCT) with Killer Cell Immunoglobulin like Receptor (KIR) mismatching. HSCT is the main mode of treatment for different Hematological Malignancies, Solid Tumors and Autoimmune Diseases. Procedure: Around 65 patients with different Hematological Malignancies were taken from Hospital Databases who underwent Allogenic HSCT from 2012 to 2018 with median age 8yrs(1yr-15yrs). Centromeric B (Cen B) motifs donor and Non Cen B motifs (Centromeric A/A) donor were evaluated and their outcome in HSCT was considered. As for the KIR B Motifs contents, they were evaluated on the basis of greater than 2 or less than 2 and their outcome on HSCT was considered. Results: In this study we found that Cen B motifs donor had the higher survival and relapse protection for pediatric hematological malignancies (DFS 56.482, 95% confidence interval 51.763-61.201, p=0.034) (RR 0.242, 95% confidence interval 0.056-1.056, p=0.044) compared to Non Cen B motifs donor. Donor with greater than two KIR B gene motifs contents had a better survival outcome and less relapse (DFS p=0.027) (RR 0.778, 95% confidence interval 0.665-0.909, p=0.025) compared to KIR B gene motifs contents less than two. Conclusion: KIR genotyping of several best HLA-matched potentials related and unrelated donors should substantially increase the frequency of better outcome in transplants by using grafts with favorable KIR gene content, KIR mismatching between donor and recipient, selecting donor with Cen B motifs and KIR B gene motifs greater than two.

Today’s children are tomorrow’s citizens. They are in a continuous process of growth and development. Any alteration in its course leads on to developmental disorders. Of the developmental disorders learning disability plays a significant role as a silent handicap among children. It is estimated that 4-5% of students in school have learning disability. Learning Disability is” A disorder that affect people’s ability to either interpret what they see and hear or to link information from different parts of the brain. Such difficulties extent to school work and can impede learning to read, write or do math”. As there are no specific test to identify children with learning disability, health professionals have to rely mainly on teacher’s report for its diagnosis. Previous studies have proved that teacher’s attitude towards such children have great influence towards their recovery.

When the COVID-19 pandemic started to spread around the world, the situation became difficult for the many educational institutions. The objective of this study was to discover the learning experiences and the expectations about the changes in education, in light of the abrupt change from face-to-face to e-learning education, of nursing students enrolled in the Bachelor’s degree of governmental universities , This study aimed to examine nursing students attitude toward e-learning. This study utilized a descriptive cross-sectional design with 50 nursing students as study participants. Data were collected via online survey tool. The imposition of e-learning sets limitations for older students, Students expressed concern about what an interruption in their nursing education would mean for their future careers as Registered Nurses. Many students in clinical placements were in their final focus clinical practicum, and thus close to successfully completing their program. Some learners were only one or two courses away from completion of their Bachelor of Nursing degree. In addition to cancelling their current clinical placement, they had concerns about progressing in the rest of their program. Digital Health Insights provide healthcare leaders and experts with the latest artificial intelligence and digital transformation news, trends, and strategies in healthcare today. Our goal is to empower you with innovative ways to collect, pool and analyse high-quality data from which you can extract actionable insights. Through artificial intelligence and digital trends in healthcare, we can use these insights to create efficiencies that improve patient care while reducing or streamlining healthcare costs.