The evolution of knowledge regarding the anatomy of the intestine throughout Greece-Arabic period and the Modern period is described. The common opinions of this organ at various points throughout this timeline are shown. The original words of great physicians from the period of time stretching from Ancient Egypt to the Avicenna era and hakim Kābbiruddin are quoted and discussed to demonstrate how knowledge of the intestine has evolved. Unani Medicine is a medical system that treats with the management of health and disease. Jalinus (Galen, 200 AD) observed that Small intestine heal more quickly and with lesser complications than wounds of the large intestine because of good blood supply. Avicenna stated that duodenal mucosa lacked the circular folds of mucosa (plicae circulares) found in the jejunum and ileum. According to Avicenna, the jejunum has a abundant blood vessels. It consisting of large, tall and closely packed circular folds of mucosa than the ileum.

Bullous pemphigoid (BP) represents one of the most prevalent forms of bullous diseases. Nevertheless, its localized variant, known as Localized Bullous Pemphigoid (LBP), is relatively uncommon, comprising only 2.5% of all BP cases. LBP is typically associated with trauma and may manifest on any wound or surgical site. Although chronic venous stasis has not been well-documented as a predisposing factor. We present the case of an 80-year-old man who exhibited blistering lesions localized to his left lower limb. He had a history of chronic venous insufficiency (CIV) on both legs, with no improvement after surgery. Clinical-pathology correlation concluded with the diagnosis of LBP. Treatment with clobetasol topical ointment and compression therapy led to complete remission of the skin lesions after one month. This report underscores chronic venous stasis as a contributing trigger for LBP.