Coronary artery disease is a complex syndrome to get initiation from formation of atherosclerotic plaques in systemic circulation to cardiac arrhythmia causing morbidity/mortality. This study was conducted to compare hypolipidemic effects of Niacin and Indian date (Jujuba) in hyperlipidemic patients. Study was conducted from July 2019 to December 2019 at National Hospital Lahore-Pakistan. Sixty participants were enrolled of both gender male and female patient’s age range from 25 to 60 years. Consent was taken from all patients. They were divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the period of two months. All patients’ systolic and diastolic blood pressure was noted. Their baseline LDL and HDL cholesterol was determined by conventional method of measuring Lipid Profile. After two months therapy, their post treatment blood pressure and lipid profile was measured and mean values with ± SEM were analyzed biostatistically. Group-I which was on Niacin their blood pressure was reduced but it was non-significant change, LDL cholesterol decreased significantly and HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was decreased significantly but HDL increase was not significant with p-value of >0.05. It was concluded from the research work that Niacin is potent in lowering LDL and increasing HDL cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it does not increase HDL cholesterol significantly. Jujubes and vitamin B-3 did not reduced blood pressure, when analyzed statistically.

Background: Neuroendocrine tumor of the appendix is a rare neoplasm discovered only incidentally. They are mainly found in the histological examination of appendices operated due to acute appendicitis. The treatment is essentially surgical, and depending on the size of the lesion, it can range from a simple appendectomy to right hemicolectomy. Case presentation: In our work, we report the case of a neuroendocrine tumor of the appendix in a 15-year-old female patient admitted for symptoms of acute abdominal pain. She was diagnosed with appendicular peritonitis and admitted to the surgical unit. The anatomopathological examination of the vermiform appendix obtained after appendicectomy showed a histological aspect of a neuroendocrine tumor. Conclusion: We recommend that appendectomy specimens be routinely sent for pathological examination malignancy and NETs, may be missed without histopathological examination.

Penile Fournier's gangrene is extremely rare due to the rich blood supply of the penis. It has only been reported in a few cases in the literature. Prompt surgical exploration, antibiotic therapy, and meticulous postoperative care are the cornerstone in the successful mangement of this high-mortality emergency. We present a rare case of penile Fournier's gangrene with total necrosis of the penis necessitating penectomy in a 70-year-old patient who is well advanced, with complete perineum healing. The goal of this article is to illustrate this rare case, as well as to explain what causes it and how to manage it.