β-thalassemia minor is a hereditary hemoglobinopathy characterized by a reduction in β-globin synthesis, usually presenting as mild, microcytic anemia. Although generally asymptomatic, pregnant women with this condition may pose anesthetic challenges due to altered hematologic and physiological states. In this case, a patient with β-thalassemia minor underwent a cesarean section under combined spinal-epidural anesthesia without complications. The anesthetic technique provided effective sensory blockade and stable hemodynamics, demonstrating that regional anesthesia can be safely administered when accompanied by appropriate preoperative evaluation, vigilant intraoperative monitoring, and effective blood conservation strategies. This case underscores the importance of individualized anesthetic planning for patients with hemoglobinopathies undergoing obstetric surgery.