This study aimed to evaluate the therapeutic potentials of extracts from medicinal plants (Vernonia amygdalina, Ocimumgratissimum, Talinum triangulare) against DDVP-induced renal toxicity in Wistar rats. A total of 50 male adult rats, each weighing approximately 272g, were divided into ten groups (n=5). The groups were given normal saline (normal control), 8.0mg/kg body weight DDVP (positive control), 8.0mg/kg body weight DDVP along with 200mg/kg and 400mg/kg body weight of the plant extracts respectively, and 20mg/kg and 40mg/kg body weight of vitamin C for 28 days. DDVP significantly (P<0.05) increased urea, creatinine, Na+, K+, Cl-, and significantly (P<0.05) decreased HCO3- compared to the normal control. Treatment with the aqueous leaf extracts of Vernonia amygdalina, Ocimumgratissimum, and Talinum triangulare significantly corrected these biochemical imbalances when contrasted with the positive control. Histology of the kidney tissues supported these findings. In conclusion, the aqueous leaf extracts of Vernonia amygdalina, Ocimumgratissimum, and Talinum triangulare may have therapeutic potential against DDVP-induced renal toxicity in rats.

Zainacin Dadin duniya is known for its antioxidant and liver-protecting properties. This research assesses the phytochemical characteristics and impact of Zainacin Dadin Duniya water extract on growth and hematological factors in Wister rats with acetaminophen-induced liver damage. 60 female and 30 male rats were divided into five groups with each group consisting of 18 rats selected randomly. Group 1 received saline, group 2 received a liver medicine, group 3 received acetaminophen, group 4 received a daily dose of aqueous extract at 500 mg/kg, and group 5 received a daily dose of aqueous extract at 500 mg/kg along with 3 ml/day of acetaminophen, all administered for 28 days. The animals were weighed before and following the experiment. The hematological parameters were determined, including packed Cell Volume (PCV), Red blood Cell (RBC), Haemoglobin (Hb), Mean Cell Volume (MCV), and White Blood Cell (WBC). Findings indicated that the extract contains a considerable quantity of phytochemicals. Findings indicated a notable weight gain (P<0.05) in Groups 1, 2, 4, and 5 and weight reduction in Group 3. In Group 3, there was a significant decrease in erythrocyte counts (4.29%), packed cell volume (33.00%), and hemoglobin (6.17%) values, while there was an increase in leukocyte (9.62%) and Mean Cell Volume (54.33%) values compared to the other groups. The presence of acetaminophen in the treatment given to Group 3 rats could lead to a decline in their growth performance and trigger adverse reactions in their blood parameters, potentially impacting their overall development. The segment may act as a strong remedy for acetaminophen-induced hepatocytes by blocking those reactive oxygen species.