Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune rheumatological disorder manifested by several clinical presentations. It may coexist with catastrophic antiphospholipid syndrome (CAPS) which is a life-threatening unusual form of Antiphospholipid syndrome (APL) with a high mortality rate and adverse sequels in survivors. A 20-year-old Sudanese female diagnosed with SLE associated with APL and complicated with probable CAPS following malaria. The patient was treated with glucocorticoids, anticoagulants and supportive treatment. Due to the financial burden neither IVIG nor plasma exchange was administered- which are the standard of care. The end result was peripheral digital gangrenes with autoamputation of the second, third, fourth and fifth fingers. This case report highlights the importance of early recognition of CAPS as a devastating form of APL which requires rapid intervention and management; we find the outcome in such patient is acceptable.