Background: Ferula assa-foetida L has several therapeutic effects such as anticancer traits. The aim of this study was investigation of anticancer effect of Ferula assa-foetida gum alcoholic extract against CT-26, HT-29, SW742 and WiDr colorectal cancer cell lines. Methods: The hot extract was obtained by soxhlet using 70% ethanol solvent. Various cell lines were cultured in DMEM medium and in vitro anticancer effects using MTT assay was performed. A dilution (5, 10, 25, 50 and 100µg/mL) of the gum extract were subjected to cell lines in triplicate. and incubated for 24, 48 and 72hrs. The main phytochemicals within the gum extract were detected through Gas and mass chromatography. Results: cytotoxicity rates were observed at 50µg/mL and >100µg/mL, respectively for all cell lines. And morphological change was noticed after 72 hr. application of the gum extract on SW742 cell line. The compounds found in the Ferula assa-foetida L mostly included oxygen-containing sesquiterpenes (45.25%) and sesquiterpenes (30.45%). Conclusion: the viability decreasing was observed for all examined colorectal adenocarcinoma cell lines including SW742, CT-26, HT-29 and WiDr lines depend on time and concentration of the applied extract of F. assa-foetida gum. The potent cytotoxicity was observed in 50-100 µg/Ml. Furthermore, a morphological change was detected after 72 hr. on SW742. A high percentages of anticancer compounds which were detected within the gum extract supports the idea of purifying these components and considering them in cancer drugs, phytochemistry.

The importance of this appraisal is on the utilization and possible of entomopathogenic roundworms (EPNs) as biotic regulator factors in maintainable nutrition manufacture transversely an extensive variety of agronomic and extra supplies. To help by the consideration of the possibility of EPNs in supportable nutriment construction, this evaluation to offers impressions on EPN biology and environmental science, conglomerate manufacture and implementation expertise, and communications through additional organization gears. Primary find out in the 1920s, their trade as biopesticides in the 1980s was attended and pursued via exponential development in investigate on their implementation, biology, and ecosystem sought via a more increase in extra rudimentary investigate regions then the middle-2000s. This assessment précises important advancement completes in the study and implementation of EPN in insect pest administration in significant nutrition yields inclusive groves, minor fruitiness, corn, vegetative, corm yields, glasshouses, and bourgeons. Noteworthy agents impacting the achievement of EPN caramelization are similarly argued. An increasing benefit in substitutes to artificial insecticides and in biological cultivation unbolts chances intended for EPNs, nonetheless, EPNs will necessity to be additionally enhanced by a concern to effectiveness, decreased charges, and facility of utilizing. Furthermore, they're probable to reprocess harbor inhabitants and seduce them to be more invested for an extended period of pest repression.