Thyroid hormones and renal function known to interact. To understand the role of thyroid hormones, play in the onset of chronic kidney disease (CKD) to management of individuals with both thyroid and renal dysfunction. This connection still causes confusion and debate because some things about it are still unknown. The aims of this work study the correlation between thyroid hormone disruptions and renal function CKD and hypothyroidism patient and their effect in Vitamin D3, parathyroid hormone (PTH) level and calcium level. In this research, there are 60 participants (20-45 years old) with both gender; 40 patients that divided in two group, the first group 20 patient has CKD and 20 patient has hypothyroidism. A control group with 20 healthy participants where included in this study. The blood sample (5ML) drawn from each participant then centrifuged to obtain the serum that used to determine the level of thyroid hormone level (TSH, T3 and T4), PTH, Albumin and vitamin D3. In addition, determined uric acid, blood urea and creatinine. The results show there is significantly increase in the TSH level in hypothyroidism patient and CKD group. While T3 and T4 group decrease significantly in hypothyroidism and CKD patient. The level of creatinine was significantly increase in CKD and hypothyroidism patients also the level of blood urea was significantly increase in CKD patient. In addition, there is no different in the level of uric acid and albumin among these two group. The level of PTH increase significantly, while the level of Ca significantly decrease in CKD patient group and D3 was significantly decrease in both patient group. It is possible to conclude that individuals with chronic kidney disease (CKD) are more likely to experience hypothyroidism; also, hypothyroidism can increase the risk of chronic kidney disease.