Optimizing patient local and systemic circumstances, as well as creating an optimum wound healing environment, are essential components of successful wound care. Many products have been developed to impact the wound environment in order to offer a pathogen-free, protected, and moist environment in which to heal. In the wound healing cascade, newer items are being employed to replace or supplement various substrates. The latest applications of silver in microbial prophylaxis and treatment, including issues involving resistance and side effects, the latest uses of negative pressure wound devices, advanced dressings and skin substitutes, biologic wound products, including growth factor applications, and hyperbaric oxygen as an adjunct in wound healing are all covered in this review of the current state of the art in wound-healing products. With so many options, it's easy to get overwhelmed.