Hyperbilirubinemia refers to an elevated level of bilirubin in the blood. Bilirubin is a yellow pigment produced during the normal breakdown of red blood cells. It is processed by the liver and excreted in bile. When bilirubin levels rise above normal, it can cause jaundice, a condition characterized by yellowing of the skin, eyes, and mucous membranes. Hyperbilirubinemia is common in newborns due to immature liver function and is usually transient. However, untreated severe cases can lead to complications like kernicterus (brain damage).there are three types of Hyperbilirubinemia: Physological jaundice due to hemolysis of blood cell, pathological jaundice due to pathological disorders such as rubella, and bacterial septicemia, Breast Milk Jaundice resulting from a combination of genetic and environmental factors such as the components of breast milk , Hemolytic Jaundice due to many reasons : Rhesus hemolytic disease, Blood group incompatibility, Glucose-6 phosphate dehydrogenase deficiency and minor blood group incompatibility.