Phytochemicals are chemical molecules found in plants, possess physiological activity, and provide other health benefits to humans besides those of macronutrients and micronutrients. The plant, Curcuma Longa, scientifically referred to as turmeric, is a strange plant that finds some applications as a spice, dye, cosmetic, and medicine. The purpose of this study was to determine the antidiabetic efficacy of Curcuma longa leaves and also to determine the bioactive chemicals that could be found in the plant. The bioactive chemicals were extracted in the Soxhlet technique using GC-MS. Based on the results of the GC-MS, the water-based extract of the Curcuma longa leaves contained eleven chemical components. These are: 2, 6- Octadienal, 3- 7 Dimethyl -(E, 0 -Terpinene, o-Cymene, Dodecane, Hexadecanoic acid, methyl ester, n- Hexadecanoic acid, 9,17- Octadecadienal, Curcumene, Epiglobulol, Caryophyll Analysis of Curcuma longa leaves extract by GC-MS revealed that it contained bioactive constituents that had potential significant medicinal effects. As per the kind of extract (Crude, Ethyl acetate, Ethanol, Water and acarbose (Standard) indicated (95.71±0.68), (41.98±0.39), (63.00±0.41), (68.04±0.49), (19.11±0.08) and (19.11±0.08) respectively against 1-amylase. Although, recorded (61.002.22), (45.172.36), (31.276.76), (49.002.46), and (12.261.72) respectively inhibitory-potency against Alpha- glucosidase activity. Thus, the presence of these bioactive substances can explain the medicinal properties of the plant and this may result in the production of new antidiabetic drugs.