Tuberculosis (TB) is a major health concern as well as leading infectious killer disease in man caused by the bacterium Mycobacterium tuberculosis. This study was carried out to assess the effect of tuberculosis on some specific coagulation factors (F VII and F XII), PT, APTT and D-Dimer). It wias caried out at the Tuberculosis and Leprosy Hospital Igbogene, the Federal Medical Center (FMCY) and Niger Delta University Teaching Hospital (NDUTH) all in Yenagoa Local Govt Area of Bayelsa state, Nigeria. Ethical approval and participant’s informed consent were obtained. Fifty (50) newly diagnosed TB subjects and 50 apparently healthy control subjects participated in this study. Specimens used were Sputum and blood. PT was assayed by the Quick one stage method. Fortress diagnostics reagents were used for the APTT assay while D-Dimer was tested by the sandwish immunodetection method by ICHROMAX. The data gathered from this research were analyzed using SPSS statistical software version 20.0. The results for the haemostatic parametres shows significantly higher (p<0.05) PT, APTT, and D-Dimer values, but significantly lower (p<0.05) F VII in newly diagnosed TB subjects when compared to controls group. There was no significant difference (P>0.05) in F XII in newly diagnosed TB subjects when compared to the controls. The results from this research indicates that Tuberculosis disease greatly altered almost all the, haemostatic, parameters studied, except coagulation factor XII that was virtualy unaltered.