Abstract: Neurodegenerative diseases are ailments that disturb the brain, precisely the neurons. The utmost mutual indicators include failures in stability, inhalation, movement, reflexes, motor skills or heartbeat activity. These can be prevented using ordinary antioxidants, like vitamins E and C, flavonoids, and polyphenols compounds. Antioxidants show a substantial effect in human’s health since they can ameliorate aging by fighting free radicals. Precisely Vitamin C can serve as a commanding antioxidant in reducing the consequence of oxidative injury triggered by pollutants, anxiety and poor diets amongst others. Hence it reduces the long-term risk of neurodegenerative diseases. Currently, neurodegenerative diseases have no cure, but they can be managed. This diseases management reduces the symptoms so as to sustain the value of life. Management with natural antioxidants such as polyphenols through diet or dietary supplements with lots of benefits have become an attractive alternative. The present knowledge on antioxidant in the treatment of neurodegenerative disorders and future bearings will be discussed and also assess the value for antioxidants as neuroprotective.