Hydrazones are an important class of biologically active molecules and could be synthesized from various methods. Similarly 2,4-dinitrophenyl hydrazine derivatives of 4-methoxyphenyl propenone chalcones are equally important hydrazones that were synthesized by the coupling of 2,4-dinitrophenyl and the 4-methoxyphenyl propenone chalcones counterparts. The coupling reaction resulted in making non - reactive 4-methoxyphenyl propenone chalcones becoming more reactive by exhibiting antibacterial, antifungal and anti-oxidant activity.