The computer produced a chromatogram, a graph based on the signals, while the instrument was running. With each peak signalling the elution of a substance from the gas chromatography column into the detector, the chromatogram revealed the process. The signal strength was used to quantify the component in the injected sample and the RT was plotted on the X-axis. After passing through the Gas chromatographic column and then the electron ionisation (mass spectroscopy) detector the compounds were broken up during elution. It was discovered that the pieces found were ions, ions are charged and each ion has a particular mass. The mass spec graph, which is like a fingerprint for molecules, was used to tweak the mass-charge ratio, M/Z. Initial oven temperature, gas flow rate, and electron gun programming was necessary for gas chromatography and mass spectrometry studies of the extract. The oven was heated to 100°C and kept at that temperature during the whole process. Polymorphism occurs when there are more than one crystalline form of a drug. All polymorphs have the same molecular formula, but different solubility and other physicochemical properties which make them exert different pharmacological effects on the human body. The aim of this study was to investigate the role of solvent polarity and processing conditions on the crystallisation and the physicochemical properties of Dexamethasone. The crystals were produced under different processing conditions such as deep freezing, law temperature cooling (4C°) as well as room temperature. Microscopy and Fourier transform infrared spectroscopy were used by the researchers to hunt for drug polymorphisms. Results showed that the crystals' physicochemical properties were affected by solvents and processing parameters. Distinct spectra were picked up using FT-IR. The properties of crystals can be modified by changing the processing conditions and polarity of the solvent used.