Background: Asthma is a common chronic respiratory disease characterized by variable respiratory symptoms and airflow limitation. Despite the availability of effective therapies, a substantial proportion of patients continue to have uncontrolled asthma. Identification of clinical and treatment-related factors associated with poor control is important for improving patient outcomes. Objective: To study the clinical profile and factors associated with uncontrolled asthma among adult patients attending the Medicine Clinic of a tertiary care hospital. Methods: A hospital-based observational study was conducted among 30 adult patients with clinically diagnosed asthma attending the Medicine Clinic. Sociodemographic and clinical details, including age, sex, duration of asthma, smoking or passive smoke exposure, previous exacerbations, comorbidities, medication adherence and inhaler technique, were recorded using a structured proforma. Asthma control was assessed using the Asthma Control Test (ACT). Patients were categorized as having controlled or uncontrolled asthma according to their ACT score. The association between selected clinical and treatment-related factors and asthma control was assessed using appropriate statistical tests. Results: Among the 30 participants, 17 (56.7%) were females and 13 (43.3%) were males. The largest proportion belonged to the 31–45-year age group (33.3%). Overall, 18 (60.0%) patients had controlled asthma, while 12 (40.0%) had uncontrolled asthma. Previous exacerbation was significantly associated with uncontrolled asthma (p=0.017). Longer duration of asthma (>10 years) was also significantly associated with poor control (p=0.018). Incorrect inhaler technique was significantly more frequent among patients with uncontrolled asthma (p=0.026). Similarly, poor medication adherence showed a significant association with uncontrolled asthma (p=0.018). Smoking exposure and comorbidities showed higher proportions among patients with uncontrolled asthma but did not demonstrate statistically significant associations. Conclusion: Uncontrolled asthma was common among adults attending the Medicine Clinic. Previous exacerbations, longer disease duration, incorrect inhaler technique and poor medication adherence were important factors associated with poor asthma control. Routine assessment of asthma control, inhaler technique and medication adherence may help improve asthma management.