A diminished circulating thyroid hormonal concentrations, alterations to peripheral hormone metabolism, disrupted binding to carrier proteins, potential decrease in tissue thyroid thyroid hormone content, and an increased iodine store in the glands of the thyroid are some of the ways that chronic renal failure (CRF) impacts thyroid function. The goal of the research is to determine whether thyroid function and chronic renal failure are related. Furthermore, we attempted to investigate how CRF affected serum creatinine in relation to thyroid hormone levels (T3 and T4) with thyroid stimulated hormones (TSH). This study included 40 healthy individuals as a baseline group (20 male, 20 female) and 15 patients with chronic renal dysfunction (25 male, 25 female). The age range was between 20 and 60. Each including the two groups had measurements of T4, T3, TSH, urea, and creatinine. The findings showed a statistically significant decrease in T3 and T4, but an increase in TSH, urea, uric acid, as well as creatinine in the patient group relative to the control group.