The presence of pharmaceutical contaminants, particularly antibiotics such as tetracycline (TC) and oxytetracycline (OTC), in aquatic environments has raised significant environmental and health concerns. This study investigates the efficiency of electrocoagulation (EC) as an advanced treatment method for the removal of TC and OTC from aqueous solutions. Electrocoagulation was conducted using aluminum electrodes under varying operational parameters including current density, initial pH, electrolysis time, and initial antibiotic concentration. The results demonstrate that EC is highly effective in reducing TC and OTC concentrations, achieving removal efficiencies exceeding 90% under optimal conditions. Optimal conditions to remove TC and OTC found to be: the initial concentration = 30 mg/L, spacing between the electrodes= 1.5 cm, pH value = normal PH value (6.3), operating time = 30 min, NaCl = 500 mg/L, current density = 20mA.cm-2. The study confirms that electrocoagulation is a promising, cost-effective, and environmentally friendly method for the treatment of antibiotic-contaminated water, offering potential for large-scale application in wastewater treatment facilities. The experimental results indicated that the adsorption of TC and OTC on Aluminum hydroxide flocs follows Langmuir isotherm with the correlation coefficient values of the R2 of 0.986 and 0.984, respectively. Langmuir model indicates that the adsorption process is likely monolayer and occurs on a uniform surface with finite identical sites under optimum conditions for the electrocoagulation process.