Syzygium polyanthum (Wight) Walp, known as Indonesian bay leaf, is a plant widely used by many ethnic groups in Southeast Asia as a traditional medicinal plant. This study aims to reveal the regenerative effects of bay leaf extract on histopathological damage to the kidneys and pancreas of hyperglycemic mice induced by alloxan. The test animals were divided into 5 groups, each consisting of 5 mice. The first group was only given food and water as a control. The second group was induced by alloxan as a negative control. Groups 3, 4, and 5 were induced by alloxan and bay leaf extract at doses of 150, 250, and 350 mg/kgBW, respectively. Alloxan induction was carried out once every two days for 6 days, while bay leaf extract was given after induction once daily for 14 days. Blood glucose levels and kidney and pancreas damage scores of mice were examined on days 1, 10, and 25. The results of the experiment showed that blood glucose levels, renal dan pancreatic histopathology damage in mice decreased after being given the extract for 14 days. Thus, it can be concluded that bay leaf extract has regenerative properties against renal dan pancreatic histopathological damage in alloxan-induced hyperglycemic mice.