Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and multi-organ inflammation. Conventional treatments primarily focus on symptom control and prevention of organ damage, as no definitive cure exists. Despite advances in immunology and targeted therapies, many patients experience recurrent flares, prolonged reliance on medications, and substantial declines in quality of life. Moreover, the underlying etiology of SLE remains incompletely understood within biomedical frameworks, which seldom incorporate spiritual or karmic perspectives central to various traditional healing systems. This study therefore, examines an alternative viewpoint rooted in the teachings of the Guan Yin Citta Dharma Door, as introduced by Dharma Master Jun Hong Lu. Within this framework, SLE is conceptualized as arising from karmic obstacles and spiritual influences, particularly those linked to killing karma from past actions. The Three Golden Buddhist Practices—making vows, reciting Buddhist scriptures, and performing life liberation—are proposed as methods to eliminate karmic obstacles and ascend attached spirits, thereby facilitating healing. The present study documents the successful recovery of one SLE patient through sustained application of these practices. This outcome aligns with two previously published cases of complete cure, illustrating practical implementation and the potential for recovery or long-term remission via dedicated spiritual cultivation. These observations indicate that Guan Yin Citta Dharma Door practices may serve as a valuable complementary approach to promote holistic health and well-being, meriting further interdisciplinary research.