The commercial banks remain one of the important keys of financial intermediaries that provides Variety of services in the economy over the states around the world, therefore this paper aims to investigate the profitability of Jordanian commercial banks in Jordan. The effect of internal and external determinants of Commercial Jordanian Banks profitability has been studied in this paper, the paper utilized of annual time series both internal and external data of these determinants for the period 2008 to 2018. Using the time series analysis and panel data techniques to measure the impact of these determinants, the sample consists of 21 Banks, followed for 14 years the quantitative method in this paper focuses on the statistical. The R2 determinants within are 64% and LSD R2 is 76% thus in both R2 the independent variables interpret the changes which happen in ROE, and the R2 is good to do this the analysis and lags depend on Hanan-Quinn which is 67.72042. The groups have a common intercept and the LSDVF 3.658 is > than P-value we reject the null hypothesis, and accept the alternative hypothesis that there is a relationship between ROE and vector of (bank specific). Results indicate that for bank-specific which consist of four variables such as, credit risk, equity, loan, saving the deposit. Where the industry-specific consist of market concentration, and also the macro-economy, determinates include: GDP Per capita, lending interest rate, inflation-unemployment ratio, Total Government revenue / GDP. Money supply 2. The analysis shows that bank-specific has a positive significant sign to bank profitability. While the market concentrates have appositive effects. Meanwhile, the macroeconomic variables are beyond the scope of management control and show appositive signs.