Infective endocarditis is a disease characterized by endocardial involvement, where vegetations infected by microorganisms form on the valves, cardiac chambers, and endothelium of large blood vessels. It is potentially fatal, with an incidence of 3 to 7 cases per 100,000 people per year. Diagnosis is made according to the modified Duke criteria, which include two major and five minor criteria. The most common infectious agents are Streptococcus viridans, Streptococcus bovis, HACEK group, and Staphylococcus aureus. Streptococcus gallolycticus is a rare causative agent in infective endocarditis, occurring in 18% of cases. Colorectal cancer is almost pathognomonic, present in up to 71% of cases, and of these, 5% are associated with prosthetic valves. For colorectal cancer, blood cultures, echocardiograms, and colonoscopies are necessary. According to the evolution time of the biological prosthetic valve, it is considered early when it presents clinical symptoms within the first year and late when it presents 1 year after the replacement.