Nurses’ asthma management practice check list was developed to closed asthma management gap. The implementation of nurses’ asthma management practice Check-list was guided by educational program to ensure adequate knowledge and reinforcement of prior learning. This study adopted Quasi-experimental one group pre-post research design in University of Port Harcourt Teaching Hospitals Rivers State, Nigeria with a Sample size of 52 nurses form the population of 103 nurses who are directly involved in asthma management, which is 50% of the population. Purposive sampling technique was utilized in this study. Check-list was used to collect data to ascertain the level of competency in asthma management practices of the participants pre and post educational program. The findings of the implementation pre/post educational program indicate good practice of asthma management post- test with 82% of the participants being able to complete their task as against 37% pre- test. The study concluded that asthma management was enhanced using check list and the use of educational program as intervention increased knowledge of asthma management. The study strongly recommended the concept of the use of educational program in implantation of check-list in nursing practice.