Women in low-resource communities are women who live in environments with limited access to economic, social, educational, and healthcare resources. Their lives are shaped by poverty, inequality, and structural barriers that affect their well-being and opportunities. The psychosocial impacts of infertility are often more intense and complex for women in low-resource communities because infertility intersects with poverty, gender inequality, and limited access to health and social support systems. The psychosocial impacts of infertility and women in low-resource communities are deeply intertwined. Infertility is not only a medical condition but a social and psychological crisis that can affect women’s identity, mental health, safety, and economic survival. Infertility among women in low-resource communities is not caused by women themselves, but is often the result of social, economic, and healthcare-related factors that increase health risks. Infertility has serious psychosocial impacts on women in low-resource communities because motherhood is often closely linked to a woman’s social status, identity, and security. This study is aim to evaluate the Psychosocial Impacts of Infertility Among Women in Low-Resources Communities in South-South, Nigeria. This was a cross-sectional study involving 250 women with age between 18 to 47 years. A well-structured questionnaire was administered to participants. The study lasted for a period of 3 months. Statistical analysis was done using SPSS version 25.0 and p < 0.05 was significant. The results revealed that 68% of the participants were married, 60% has married for more than 5 years, 60% residence in rural areas, 60% had secondary level of education, 80% were of low class, 80% have not sought medical help for infertility, 70% sought traditional healer, 68% had stress, 76% are anxious or worried, 72% are sad, 80% are pressured, 80% had relationship affected, 80% had family relationship affected, majority had economic impacts.