Diabetic foot ulcer (DFU) remains one of the most severe and costly complications of diabetes mellitus, and contributes to infection, amputation, and mortality on a large scale globally. This review performs an update reviewing the literature about epidemiology and principal risk factors for development of DFU. Recent global data indicate that the DFU affects ~6% of those who have diabetes, while prevalence in different areas of the world is quite variable because of disparities in access to care, social conditions and impediments to preventive care. DFU is a multifactorial disease that stems from the interactions among peripheral neuropathy, PAD, biomechanical abnormalities, metabolic disorder and wound healing defects. In the extant literature, multiple risk factors for DFU are once again described, including duration of diabetes, male sex, age older than 45-50 years, poor glycemic control, hypertension or metabolic syndrome abnormality [1], obesity overweight [3], and central fat accumulation with elevated waist: hip-ratio anorexia nervosa defined as related to a BMI less than 17.5 but also as a low volume intake such us reaching an initial idea more important rectal bleeding and syndromes following cerebrovascular accident Structural foot deformities history of ulceration or amputation current diabetic foot ulcer (DFU) unsatisfactory footwear inappropriate podiatric care. Behavioral and environmental factors such as wearing unsuitable shoes, low health literacy, and living in rural areas further add to vulnerability in several populations. Awareness of these common trends and predictors is essential to trigger improved preventive measures, help in risk stratification, and guide evidence-based clinical decisions. In the context of summarizing new evidence, this article reinforces the ongoing requirement for early screening, organized foot programs, and select interventions to diminish the devastating effects of DFU and its sequelae.