Students' academic performance, in Internet era with increasing misuse of social media interfere with study habits. This study explored the effect of social media on academic performance among medical students, in three (3) River Nile State Universities in Northern Sudan. It was cross sectional study conducted on three hundred and eighty (380) medical students from April to October 2024. Participant’s students from Elsheikh Abdallah Elbadri University (EAEU) representing the largest portion (40.5%) Most students (63.4%) were aged (20 to 25) years with females comprising (57.1%) of participants. Nearly all students (96.6%) used social media primarily for non-academic purposes, and (58.9%) spent over four (4) hours daily on these non- academic sites. The majority reported that social media negatively impacted their academic Performance (62.4%) and affected their sleep (54.7%). About (75.8%) had implemented strategies to minimize social media effects on their academic and personal lives such as setting time limits or deleting certain applications.