Oedema is defined as accumulation of water in the extravascular cell, which is in the normal conditions, total body water should be regulate between intravascular and extravascular to maintain normal concentration and any dysfunction of these mechanisms lead to edema which occurred by different pathways, either excess fluid filtrations or inadequate drainage of interstitial tissues by lymphatic vessels. In other hand, when liquid accumulated in the tissues by retention or swelling in the feet or hands can lead to skin tight, feel heavy, pain joint. Recent studies refer to complications related to edema includes circulation of blood, clotting, obesity, liver and kidney disease in addition to heart injuries with the lymph nodules. The result include a comparison between some important biochemical changes between control and patients’ groups, data were collected from thirty patients and thirty healthy people, there was noticed in the study, no significant increase in the levels of AST and ALT while appeared significant increase in ALP in patients compared with control group, and no significant decrease in albumin in patients compared with control group, also there was no significant decrease in levels of Na+ and K+ while appeared significant decrease in Cl_ in patients compared with control group, finally there was no significant increase in glucose while appeared significant decrease in Hb in patients compared with control group.