Environmental studies have shown outstanding antibacterial properties of the Zingiber officinale. Ginger is antimicrobial in nature, and is known as scientifically belonging to Zingiber officinalis. It can be stated that its extracts, particularly ones containing a lot of gingerol and other chemicals, have been proven to be effective against multiple harmful pathogens. The findings support the possible application in ginger as a natural antibacterial as well as the historical uses in the treatment of bacterial diseases. The functional groups that reflect in the group recorded in the ginger powder samples on the entire mid-infrared range (4,000-650 cm -1) measured were =C -H, alkenes, C-F, alkyl halides, C=C, aromatic, and N-H, amide. Radical scavenging activities [Hydroxyl radical scavenging] of crude (methanolic extract), ethanol, hexane and water fractions of Zingiber officinale (ginger) compared with Mannitol (standard) were 126.95+3.97, 217.77+6.19, 149.01+4.73, 193.42+5.00, and 531.96+26.09 respectively. While recorded 31.05±1.07, 38.54±1.20, 30.45±1.18, 41.00±1.27 and 53.08±2.00 respectively comparison with Quercetin (standard). In vitro antimicrobial activity of Ginger (Zingiber Officinale) extracts on five microorganism: according to the type of extract (methanol, ethyl acetate fraction, ethanol fraction, comparison with standards AP-Ampicillin and CF-Cephalothin) recorded 18.00±0.38, 14.00±0.34, 23.00±0.41, 25.09±0.44 and 23.96±0.42 respectively for Klebsiella pneumoniae. While recorded 20.95±0.39, 16.00±0.35, 24.00±0.42, 27.08±0.47 and 25.00±0.43 respectively for Escherichia coli. At the same time record 23.00±0.41, 17.09±0.36, 22.00±0.40, 29.17±0.49 and 31.05±0.51 respectively for Streptococcus pyogenes. While recorded 17.09±0.38, 25.08±0.44, 20.81±0.39, 31.00±0.50 and 28.39±0.48 respectively for Staphylococcus aureus and recorded 19.65±0.40, 27.00±0.47, 30.07±0.50, 35.19±0.54 and 31.00±0.51 respectively for Bacillus subtilis.