Pulmonary aspergillosis is an opportunistic infection caused by species of the genus Aspergillus, encompassing a broad clinical spectrum, from saprophytic colonization to potentially fatal invasive disease. Among its chronic forms, aspergilloma represents an intracavitary fungal mass, usually associated with pre-existing pulmonary cavities due to tuberculosis, emphysema, or other structural lung diseases. Although classically considered non-invasive, it may cause severe complications in specific clinical settings. Pulmonary Aspergillus infection can present atypically, especially in immunocompromised patients. Thrombotic events, including pulmonary thromboembolism (PTE), have been described as rare but possible complications in these patients.