Background: Postoperative infection is a significant concern in mandibular fractures treated by open reduction and internal fixation (ORIF). Platelet-Rich Fibrin (PRF) has emerged as a biomaterial that supports wound healing and reduces inflammation. This study aimed to evaluate the efficacy of PRF in reducing postoperative infections in simple mandibular fractures under short antibiotic regimens. Methods: A prospective comparative clinical study was conducted on 31 patients (32 fracture sites) with simple mandibular fractures requiring ORIF. Patients were randomly divided into PRF (n=16) and non-PRF (n=16) groups. Both groups received identical preoperative and perioperative antibiotic coverage. Postoperative infection signs were assessed clinically on the 3rd, 7th, and 14th days. Results: The PRF group demonstrated better early pain reduction and healing outcomes. Although clinical signs of infection such as erythema, wound dehiscence, and fever were less common in the PRF group, the difference between groups was not statistically significant. Conclusion: PRF shows potential to enhance postoperative healing and reduce minor complications in mandibular fracture management. However, its benefit in preventing infection was not statistically conclusive.