Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculopathy that typically presents with neurological symptoms within four weeks of a preceding infection. It is characterized by symmetrical, ascending muscle weakness and areflexia, often sparing cranial nerves. Two therapeutic modalities are currently established—intravenous immunoglobulin (IVIG) and plasmapheresis—with comparable efficacy. Despite treatment, a subset of patients may experience severe functional impairment or even mortality. We present the case of a patient with GBS who showed poor response to IVIG, developed respiratory failure, and underwent prolonged hospitalization with multiple complications. A multidisciplinary team enabled home discharge with mechanical life-support ventilation, facilitating continued rehabilitation in a safer, non-hospital environment.