Context: Diabetic ketoacidosis (DKA) is a common and severe side effect of type 1 diabetes mellitus (T1DM) in children and adolescents, requiring prompt and accurate treatment. Aims: The current study aimed to estimate nurses' knowledge and confidence in managing DKA, investigate their relationship with sociodemographic factors, and determine the correlation between nurses' knowledge and self-confidence. Settings and Design: The current study adopted a cross-sectional approach in four teaching hospitals in Baghdad city. Methods and Material: This descriptive cross-sectional study included nurses from four Baghdad hospitals. A proportionate stratified random sampling method selected 200 nurses from distinct departments. A standardized, validated questionnaire assessed nurses' sociodemographic features, knowledge, and self-confidence in managing diabetic ketoacidosis. Cronbach's alpha of 0.79 validated the questionnaire's dependability. Statistical Analysis: In SPSS, the researchers calculated mean scores, Spearman's rank test, and Pearson's analysis. Results: The results proved that the participants’ overall knowledge and self-confidence were unacceptable. The study also demonstrated a positive relationship between education level and their knowledge of managing DKA. A statistically significant relationship was also found between the training courses nurses received about DKA and their confidence in managing DKA. The study finds a statistically significant correlation between nurses' self-confidence and their level of knowledge. Conclusions: Although nurses' general knowledge and confidence in managing diabetic ketoacidosis were moderate, the results indicated room for improvement, particularly in practical aspects. It was also found that the effect of educational level on the variables of knowledge and training among nurses improves confidence.