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South Asian Research Journal of Applied Medical Sciences (SARJAMS)
Volume-7 | Issue-04
Case Report
Fast-Track Melanoma Metastatic: A Case Report of Accelerated Progression
Camacho-Cedeño Laura Patricia, Chávez-Chavira Grecia, Ramirez-Hernandez Vianca Andrea, Rolon-Aguilera Sharon Danai
Published : July 7, 2025
DOI : https://doi.org/10.36346/sarjams.2025.v07i04.003
Abstract
Metastatic malignant melanoma is the most lethal cutaneous neoplasm, originating from melanocytes and characterized by aggressive behavior and distant dissemination via lymphatic and hematogenous routes. Risk factors include phenotypic traits, genetic mutations, and environmental exposures. Histologically, it presents with atypical melanocytes invading the dermis, often showing nuclear pleomorphism, mitoses, and ulceration. Breslow thickness is the key prognostic indicator. Management is multidisciplinary, with surgical resection as first-line when feasible. In unresectable cases, treatment is guided by molecular profiling. We present the case of a 81-year-old female with rapid progression of the disease and ganglionar metastases.

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