The African species Albizia anthelmintica L. and Guiera senegalensis, L. were obtained from Alnahud town, West Kordofan State Sudan and the samples were identified by plants taxonomist at Department of Horticultural Sciences, Faculty of Agricultural Sciences, University of Gezira, Sudan and then the constituents were extracted by maceration method using ethanol 70% and distilled water. Qualitative analysis was carried out to identify the different classes of secondary metabolites in the plants extracts using conventional chemical tests. All the tested plants A. anthelmintica and G. senegalensis leaves extracts showed the presence of; tannins, flavonoids, saponins, phenols, phytosterols, carbohydrate, amino acids and proteins, while alkaloids, cardiac glycosides and glycosides were absent in both aqueous and ethanolic extracts of A. anthelmintica. And carbohydrate, glycoside were absent in both aqueous and ethanolic extracts of G. senegalensis. The observed antibacterial effects of ethanolic extract of A. anthelmintica demonstrated the highest activity against Staphylococcus aureus and Escherichia coli. The Antioxidant activity DPPH solution exhibit a purple color with a high absorbance, so the extracts showed significant antioxidant activity.