Cardiac amyloidosis is characterized by the extracellular deposition of misfolded proteins. Currently, there are more than 30 proteins that can form amyloid fibrils in vivo, 9 of which accumulate in the myocardium. A 70-year-old male with a history of supraventricular tachycardia, type 2 diabetes, systemic arterial hypertension, and prostatic adenocarcinoma. As part of the treatment for bone metastases due to a history of cancer, a Tc99m methylenediphosphonate bone scan was performed, revealing an abnormal increase in myocardial bone turnover. A technetium-99 (Tc99) and pyrophosphate cardiac scan was performed, yielding a positive result for infiltrative process (AC-ATTR), Perugini 3, and H/CL ratio of 1.52. Based on cardiac scan findings of infiltrative process, absence of a polyclonal light chain spike, and a negative ATTR gene, the diagnosis of ATTRwt cardiac amyloidosis was reached.