Psoriasis is a chronic inflammatory skin disease with a complex and multifactorial pathophysiology. Among the triggering factors, certain medications have been implicated as causing the appearance of new cases or exacerbations in previously diagnosed patients. This article reviews the latest evidence on medications associated with induced psoriasis, paradoxical eruptions, the pathophysiological mechanisms involved, and clinical implications. Strategies for its management and prevention are also discussed, highlighting the importance of pharmacovigilance in these patients.