The increase in chronic diseases is reported to be the most common cause of death worldwide. This disease usually persists for a long period of time and duration with slow progression. The impact of chronic diseases is not only related to the socio-economic conditions of the patient, but also the family as the main caregiver for the patient. Families with low socio-economic status are vulnerable to chronic diseases due to high costs of care, job changes and decreased income, these conditions ultimately cause caregiver burden in families. This study aims to analyze socio-economic factors with the incidence of caregiver burden in families with chronic diseases. A cross sectional study was conducted among 120 family caregivers of patient with chronic illness purposively selected in Malang Regency, East Java, Indonesia. Data were gathered between June-November 2023 using Google form. 4 questionnare were performed. Descriptive statistic were used to summarize the data in frequencies and percentage. Linear regression analysis were used to examine correlations among variables. The majority of respondents were female (73.3%) with a patient care span of >1 year (55%), 53.3% reported having health insurance. The results of simultaneous regression analysis obtained significant data on the influence of the two independent variables in the form of social support and economic status on the incidence of caregiver burden (p value <0.05) with an R2 value of 75%. These results indicate that good social support and socioeconomic status can help reduce the burden of care on the family.