β-thalassemia is a prevalent genetic disorder characterized by chronic anemia, necessitating regular blood transfusions and resulting in iron overload, notably within the heart. This iron overload can lead to a range of cardiac complications, often culminating in heart failure, which stands as the primary cause of mortality in patients with this disorder. Early detection and timely management of these cardiac complications are paramount for ensuring the best possible outcomes for affected individuals. This article presents and discusses in detail three clinical cases, underscoring the critical importance of early screening and effective management strategies to avert fatal progression in patients afflicted by β-thalassemia.